TONGLING SHAN   Ph.D,  Associate professor   E-mail: shantongling@shvri.ac.cn Tel: +86 21-34293773 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2010-2011 Visiting Scholar, Viral Metagenomics, Department of Laboratory Medicine, University of California San Francisco, CA, USA 2008-2011 PhD, Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China 2005-2008 Master of Clinical Veterinary Medicine, Huazhong Agricultural University, Wuhan, China. 2001-2005 Bachelor of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.   Professional Experience   2014-Present, Associate Professor; Porcine Reproductive Syndrome Research Group, Shanghai Veterinary Research Institute, CAAS 2011-2013, Assistant Professor; Porcine Reproductive Syndrome Research Group, Shanghai Veterinary Research Institute, CAAS   Current Research Topics   Diagnosing emerging viral infect disease in swine by viral metagenomics Vaccine and diagnostic kit for Porcine Epidemic Diarrhea Virus Molecular mechanism of interaction between PEDV and host   Publications   1.Shan T, Li L, Simmonds P, Wang C, Moeser A, Delwart E. The fecal virome of pigs on a high-density farm. J Virol. 2011.; 85(22):11697-708.  2.Shan TL, Lan DL, Li LL, Wang CM, Cui L, Zhang W, Hua XG, Zhu CX, Zhao W, Delwart E. Genomic characterization and high prevalence of bocaviruses in swine. PLoS One. 2011, 6(4): e17292.  3.Shan T, Wang C, Cui L, Yu Y, Delwart E, Zhao W, Zhu C, Lan D, Dai X, Hua X. Picornavirus salivirus/klassevirus in children with diarrhea, China. Emerg Infect Dis. 2010, 6(8):1303-5. 4.Shan TL, Wang CM, Cui L, Delwart E, Yuan CL, Zhao W, Guo W, Dai XQ, Yu Y, Hua XG. Human parechovirus infections in monkeys with diarrhea, China. Emerg Infect Dis. 2010, 16(7):1168-9. 5.Tongling Shan, Chunmei Wang, Wu Tong, Hao Zheng, Xiuguo Hua, Shen Yang, Yifei Guo, Wen Zhang, Guangzhi Tong. Complete Genome of a Novel Porcine Astrovirus. J Virol, 2012; Accept.  6.Shan TL, Zhang W, Guo W, Cui L, Yuan CL, Dai XQ, Shen Q, Yang ZB, Zhu JG, Hua XG. The first detection of human bocavirus 2 infections in China. J Clin Virol. 2009, 46(2):196-7.  7.Shan TL, Guo W, Cui L, Shang XG, Dai XQ, Yuan CL, Yu Y, Zhang W, Zhu JG, Shen Q, Yang ZB, Hua XG. The first detection of human parechovirus infections in China. J Clin Virol. 2009, 5(4):371-2. 8.Shan TL, Dai XQ, Guo W, Zhang W, Cui L, Yuan CL, Shang XG, Shen Q, Hua XG. Human astrovirus infection in children with gastroenteritis in Shanghai. J Clin Virol. 2009, 44(3):248-9.  9.Shan TL, Cui L, Dai XQ, Guo W, Shang XG, Yu Y, Zhang W, Kang YJ, Shen Q, Yang ZB, Zhu JG, Hua XG. Sequence analysis of an isolate of minute virus of canines in China reveals the closed association with bocavirus. Mol Biol Rep. 2010, 37(6):2817-20.  10.Shan TL, Tang ZL, Guo DZ, Yang SL, Mu YL, Ma YH, Guan WJ, Li K. Partial molecular cloning, characterization, and analysis of the subcellular localization and expression patterns of the porcine OTUB1 gene. Mol Biol Rep. 2009, 36(6):1573-7.  11.Shan TL, Li K, Tang ZL, Yang SL, Ma YH, Guan WJ, Guo DZ. Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes. Mol Biol Rep. 2009, 36(4):751-6. 12.Zhu CX*, Shan TL*, Cui L, Luo XN, Liu ZJ, Tang SD, Liu ZW, Yuan CL, Lan DL, Zhao W, Hua XG. Molecular detection and sequence analysis of feline Torque teno virus (TTV) in China. Virus Res. 2011, 56:13-6. (*Co-first author) 13.Yu Y*, Shan T*, Zhu S, Zhu C, Hua X, Wang C. Prokaryote expression of HPeV-1 VP1 protein, production of VP1 polyclonal antibody and the development of an ELISA. J Virol Methods. 2012， 182(1-2):56-61. (*Co-first author) 14.Li L, Shan T, Wang C, C?té C, Kolman J, Onions D, Gulland FM, Delwart E. The fecal viral flora of california sea lions. J Virol. 2011; 85(19):9909-17.  15.Pan X, Kong N, Shan T, Zheng H, Tong W, Yang S, Li G, Zhou E, Tong G. Monoclonal antibody to N protein of porcine epidemic diarrhea virus. Monoclon Antib Immunodiagn Immunother. 2015; 34(1):51-4. 16.Wang C, Shan T, Zheng H, Tong W, Chen F, Hu H, He Q, Tong G. Complete genome sequence of a novel human parechovirus. J Virol. 2012;86(21):11945-6  17.Li L, Shan T, Soji OB, Alam MM, Kunz TH, Zaidi SZ, Delwart E. Possible cross-species transmission of circoviruses and cycloviruses among farm animals. J Gen Virol. 2011, 92:768-72. 18.Li L, Pesavento P, Shan T, Leutenegger CM, Wang C, Delwart E. Viruses in diarrhetic dogs include novel kobuviruses and sapoviruses. J Gen Virol. 2011. 92(Pt 11):2534-41.  19.Zhu CX, Cui L, Shan TL, Luo XN, Liu ZJ, Yuan CL, Lan DL, Zhao W, Liu ZW, Hua XG. Porcine torque teno virus infections in China. J Clin Virol. 2010, 48(4):296-8.  20.Zheng H, Shan T, Deng Y, Sun C, Yuan S, Yin Y, Tong G.. Molecular characterization of Japanese encephalitis virus strains prevalent in Chinese swine herds. Journal of Veterinary Science, 2013;14(1):27-36.  21.Deng Y, Shan TL, Tong W, Zheng XC, Guo YY, Zheng H, Cao SJ, Wen XT, Tong GZ. Genomic characterization of a bovine viral diarrhea virus 1 isolate from swine. Arch Virol. 2014. (Accept) 22.Dai XQ, Hua XG, Shan TL, Delwart E, Zhao W. Human cosavirus infections in children in China. J Clin Virol. 2010, 48(3):228-9. 23.Lan D, Ji W, Shan T, Cui L, Yang Z, Yuan C, Hua X. Molecular characterization of a porcine astrovirus strain in China. Arch Virol. 2011, 156(10):1869-75. 24.Zhang W, Yang S, Ren L, Shen Q, Cui L, Fan K, Huang F, Kang Y, Shan T, Wei J, Xiu H, Lou Y, Liu J, Yang Z, Zhu J, Hua X. Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area. PLoS One. 2009, 4(12):e8156. 25.Shen Q, Zhang W, Yang S, Chen Y, Ning H, Shan T, Liu J, Yang Z, Cui L, Zhu J, Hua X. Molecular detection and prevalence of porcine caliciviruses in eastern China from 2008 to 2009. Arch Virol. 2009;154(10):1625-30. 26.Zhu AL, Zhao W, Yin H, Shan TL, Zhu CX, Yang X, Hua XG, Cui L. Isolation and characterization of canine astrovirus in China. Arch Virol. 2011; 156(9):1671-5. 27.Zhao W, Hua XG, Yuan L, Cui L, Shan TL, et al. Sequence analyses of the representative Chinese-prevalent strain of avian nephritis virus in healthy chicken flocks. Avian Dis. 2011, 55(1):65-9.  28.Zhang W, Yang S, Shen Q, Huang F, Shan T, Yang Z, Cui L, Zhu J, Hua X. Genotype 3 hepatitis E virus existed among swine groups in 4 geographically far regions in China. Vet Microbiol. 2010, 6; 140(1-2):193-5.  29.Zhang W, Yang S, Shen Q, Liu J, Shan T, Huang F, Ning H, Kang Y, Yang Z, Cui L, Zhu J, Hua X. . Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China. Virol J. 2009, 16; 6:24. 30.Shen Q, Zhang W, Yang S, Chen Y, Shan T, Cui L, Hua X. Genomic organization and recombination analysis of human norovirus identified from China. Mol Biol Rep. 2012; 39(2):1275-81. 31.Lan D, Hua X, Cui L, Luo X, Liu Z, Shan T, Zhu C, Zhao W, Yang Z. Sequence analysis of a Torque teno canis virus isolated in China. Virus Res. 2011, 160(1-2):98-101. 32.Deng Y, Sun CQ, Cao SJ, Lin T, Yuan SS, Zhang HB, Zhai SL, Huang L, Shan TL, Zheng H, Wen XT, Tong GZ. High prevalence of bovine viral diarrhea virus 1 in Chinese swine herds. Vet Microbiol. 2012，In Press. 33.Zhang W, Yang S, Shen Q, Ren L, Shan T, Wei J, Cui L, Hua X. Complete genome sequence of a novel porcine enterovirus strain in china. J Virol. 2012; 86(12):7008-9.  34.Alquezar-Planas DE, Mourier T, Bruhn CA, Hansen AJ, Vitcetz SN, Mørk S, Gorodkin J, Nielsen HA, Guo Y, Sethuraman A, Paxinos EE, Shan T, Delwart EL, Nielsen LP. Discovery of a divergent HPIV4 from respiratory secretions using second and third generation metagenomic sequencing. Sci Rep. 2013,3; 3:2468.