一、个人简历

孙英杰，博士，研究员，博士生导师，现任禽病研究室副主任、国家级人才，入选中国农业科学院杰出青年英才、上海领军人才“后备队”。福建农林大学兼职博士生导师、上海微生物学会兽医微生物专业委员会主任、中国畜牧兽医学会公共卫生分会常务理事、中国畜牧兽医学会禽病学分会理事、J Integr Agr青年编委。

主要研究方向是动物副黏病毒的分子致病机制。重点关注病毒感染后诱导的固有免疫反应、代谢调控、细胞器应激以及细胞死亡等生物过程，深入探讨其在病毒复制和致病过程中的作用。主持国家重点研发计划青年科学家项目等国家和省部级项目8项。以第一或通讯作者在《Cell Reports》, 《mBio》、《Plos Pathogens》、《Journal of Advanced Research》、《Journal of Virology》、《iScience》、《FASEB Journal》等SCI期刊发表论文23篇，获授权发明专利8件，获“王泽霖基金禽病研究创新奖”。

二、联系方式

办公电话：021-34293426

邮      箱：sunyingjie@shvri.ac.cn

三、代表论著

[1] Hui Jiang, Yang Qu, Xianjin Kan, Mengqing Yang, Yabin Gong, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Venugopal Nair, Chan Ding*, Yingjie Sun*, Pexophagy-driven redox imbalance promotes virus-induced ferroptosis, Cell Reports, 2025, 44(6): 115783.

[2] Yongqi Guo, Menghang Wang, Ning Tang, Yubo Zhao, Lijing Wo , Dexin Liang, Rui Huangª, Yandong Tang*, Yingjie Sun* , Xin Yin*, Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes, Journal of Advanced Research, 2025.

[3] Yang Qu, Siyuan Wang, Hui Jiang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Venugopal Nair, Zengqi Yang*, Yingjie Sun*, Chan Ding*, Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves, Plos Pathogens, 2024, 20(12): e1012737.

[4] Yifan Sun, Lanlan Tang, Xianjin Kan, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Venugopal Nair, Chan Ding* , Xiufan Liu* , Yingjie Sun* , Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells, Journal of Virology, 2024, 98(3): e0189723.

[5] Hui Jiang, Yanfeng Liu, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Chan Ding*, Yingjie Sun*, PEX5-mediated modulation of apoptotic pathways in response to Newcastle disease virus infection, Journal of Integrative Agriculture, 2024.

[6] Yang Qu, Siyuan Wang, Hui Jiang, Qingyi Wang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Chan Ding*, Yingjie Sun*, Zengqi Yang*, The Ca2+-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity, Journal of Virology, 2024, 98(5): e0001624.

[7] Ning Tang, Pingyi Chen, Changrun Zhao, Panrao Liu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Xiufan Liu, Tingrong Luo*, Yingjie Sun*, Chan Ding*, Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication, Journal of Virology, 2023, 97(3): e0001623.

[8] Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding*, Yingjie Sun*, Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity, mBio, 2021, 12(3): e0100521.

[9] Xianjin Kan, Yuncong Yin, Cuiping Song, Lei Tan, Xusheng Qiu, Ying Liao, Weiwei Liu, Songshu Meng, Yingjie Sun* and Chan Ding*, Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells, iScience, 2021, 24(8): 102837.

[10] Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun*, Chan Ding*, ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells, Plos Pathogens, 2020, 16(6):e1008514.

[11] Yuan Zhan, Shengqing Yu, Shen Yang, Xusheng Qiu, Chunchun Meng, Lei Tan, Cuiping Song, Ying Liao, Weiwei Liu, Yingjie Sun*, Chan Ding*, Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E, Plos Pathogens, 2020, 16(6):e1008610.

[12] Yingjie Sun†, Hang Zheng†, Shengqing Yu, Yunlei Ding, Wei Wu, Xuming Mao, Ying Liao, Chunchun Meng, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Fengyun Wu, and Chan Ding*, Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5, Journal of Virology, 2019;93(18):e00322-19

[13] Yingjie Sun, Luna Dong, Shengqing Yu, Xiaoxu Wang, Hang Zheng, Pin Zhang, Chunchun Meng, Yuan Zhan, Lei Tan, Cuiping Song, Xusheng Qiu, Guijun Wang, Ying Liao, and Chan Ding*, Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation, FASEB Journal, 2017, 31

[14] Yingjie Sun, Shengqing Yu, Na Ding, Chunchun Meng, Songshu Meng, Shilei Zhang, Yuan Zhan, Xusheng Qiu, Lei Tan, Hongjun Chen, Cuiping Song, Chan Ding*. Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues. Journal of Virology, 2014, 88(1): 525-537.

四、专利标准

[1] A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF, 授权时间：2022.04.19，美国专利号：US 11,305,007,B2

[2] 一种重组表达载体、制备得到的I型鸭甲型肝炎病毒样颗粒、制备方法及应用。授权时间2023.05.05，中国专利号：ZL201910603170

[3] 一种复合多表位表达盒、其组成的重组病毒及应用。授权时间：2023.06.30，中国专利号：ZL202011211170.

[4] 一种表达Furin蛋白的细胞株及其在禽传染性支气管炎病毒培养中的应用。授权时间：2021.8, 中国专利授权号：ZL201910344592.1

[5] 稳定表达仓鼠TIGAR基因的BHK细胞系及其构建方法和应用。授权时间：2021.8, 中国专利授权号：ZL201910344592.1

[6] 一种鹅源线粒体抗病毒信号蛋白及其应用，2021-08-03，中国，ZL201810367202.8

[7] 鸡IBV S1蛋白的CD8+ T细胞抗原表位多肽，2015-04-15，中国，201310317878.3

[8] 一种具有抗新城疫病毒活性的鹅源基因RIG-I及应用，2015-12-22，中国，ZL201210281895.1