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人才队伍

邱亚峰


研究员,博士生导师

研究领域:猪呼吸道传染病及人畜共患性传染病的免疫致病机制研究
电话/传真:021-34680292(O); 021-54081818(F)
电子邮件:yafengq@shvri.ac.cn

受教育及工作经历:
1997.09-2001.06 山东农业大学 兽医学 学士
2001.09-2006.06 南京农业大学 预防兽医学 博士
2006.08-2008.12 中国农业科学院上海兽医研究所 助理研究员
2009.01-2010.12 中国农业科学院上海兽医研究所 副研究员
2011.01-2013.12 密西根大学医学院 呼吸内科系 博士后
2014.1-至今 中国农业科学院上海兽医研究所 研究员

科研方向:
现从事病原微生物感染与免疫的基础研究,集中研究猪呼吸道病毒-细菌共感染的致病机制以及人畜共患性病原感染的致病机制,主要包括:
1)猪繁殖与呼吸综合征病毒(PRRSV)感染继发细菌感染的免疫分子机制;
2)副猪嗜血杆菌(HPS)等细菌感染的免疫分子机制;
3)乙型脑炎病毒(JEV)感染的免疫分子机制。

承担科研项目情况:

  • 国家自然科学基金面上项目,31972693,巨噬细胞清道夫受体A在猪繁殖和呼吸综合征病毒感染继发副猪嗜血杆菌感染中的作用机制研究,58万,2020.1-2023.12,项目负责人,在研
  • 国家重点研发计划,2018YFD0500101,猪呼吸道病原微生物共感染与协同致病机理,40.5万,2018.6-2020.12,子课题负责人,在研
  • 国家重点研发计划2016YFD0500404病原诱导天然免疫应答及其调控机制,147万,2016.7-2020.12,子课题负责人,在研
  • 中国农业科学院青年英才计划,CAASQNYC-KYYJ-26300万,2015.1-2018.12,项目负责人。
  • 上海市自然科学基金项目,15ZR144980010万,2015.1-2017.12,项目负责人。
  • 中国农科院基本科研业务费增量项目,2015ZL06520万,2015.1-2015.12,项目负责人。
  • 国家自然科学基金青年项目,3070059317万,2008.1-2010.12,项目负责人。
  • 国家自然科学基金青年项目,3150204621万(直接费用),2016.1-2018.12,参加/导师。
  • 上海市科技兴农重点攻关项目,G2015011118万,2015.4-2018.4,参加/骨干。

 

代表性的论著:

1, Qiu, Y.F., Dayrit, J.K., Davis, M.J., Carolan, J.F., Osterholzer, J.J., Curtis, J.L., and Olszewski, M.A.* (2013). Scavenger Receptor A Modulates the Immune Response to Pulmonary Cryptococcus neoformans Infection. Journal of Immunology 191(1): 238-48.

2, Qiu, Y.F.#, Zeltzer, S.#, Zhang, Y.M., Chen, G.H., Dayrit, J.K., Murdock, B.J., Bhan, U., Toews, G.B., Osterholzer, J.J., Standiford, T.J., and Olszewski, M.A.* (2012). Early Induction of CCL7 Downstream of TLR9 Signaling Promotes the Development of Robust Immunity to Cryptococcal Infection. Journal of Immunology 188(8):3940-8.

3, Lu, Y.#, Zhang, Y.B.#, Sharma, M, Liu, K., Wei, J.C., Shao, D.H., Li, B.B., Tong, G.Z., Olszewski, M.A., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Notch signaling contributes to the expression of inflammatory cytokines induced by highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection in porcine alveolar macrophages. Developmental & Comparative Immunology 108: 103690.

4, Xiang, X.#, Zhang, Y.B.#, Wei, J.C., Liu, K., Shao, D.H., Li, B.B., Olszewski, M.A., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Expression profile of porcine scavenger receptor A and its role in bacterial phagocytosis by macrophages. Developmental & Comparative Immunology 104: 103534.

5, Wang, Z.T.#, Zhang, Y.B.#, Wang, L.Y.#, Wei, J.C., Liu, K., Shao, D.H., Li, B.B., Liu, L.H., Widén, F., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Comparative genomic analysis of Bordetella bronchiseptica isolates from the lungs of pigs with porcine respiratory disease complex (PRDC). Infection, Genetics and Evolution 81: 104258.

6, Liu, K.#, Ma, G.N.#, Liu, X.Q., Lu, Y., Xi, S.M., Ou, A.N., Wei, J.C., Li, B.B., Shao, D.H., Li, Y.M., Qiu, Y.F.*, Mao, D.N., and Ma, Z.Y.* (2019). Porcine reproductive and respiratory syndrome virus counteracts type I interferon-induced early antiviral state by interfering IRF7 activity. Veterinary Microbiology 229: 28-38.

7, Shi, Y.Y.#*, Jiang, W.#, Ma, Z.Y., and Qiu, Y.F.* (2017). A case report of pulmonary tritrichomonosis in a pig. BMC Veterinary Research 13(1):348.

8, Li, Y.M., Wu, Z.C., Liu, K., Qi, P.F., Xu, J.P., Wei, J.C., Li, B.B., Shao, D.H., Shi, Y.Y., Qiu, Y.F.*, and Ma, Z.Y*. (2017). Doxycycline enhances adsorption and inhibits early-stage replication of porcine reproductive and respiratory syndrome virus in vitro. FEMS Microbiol Lett 364(17): doi: 10.1093/femsle/fnx170.

9, Li, Y.M., Wu, Z.C., Liu, K., Qi, P.F., Xu, J.P., Wei, J.C., Li, B.B., Shao, D.H., Shi, Y.Y., Qiu, Y.F.*, and Ma, Z.Y.* (2017). Proteomic Analysis of the Secretome of Porcine Alveolar Macrophages Infected with Porcine Reproductive and Respiratory Syndrome Virus. Proteomics 17(21):doi: 10.1002/pmic.201700080.

10, Qi, P.F.#, Liu, K.#, Wei, J.C., Li, Y.M., Li, B.B., Shao, D.H., Wu, Z.C., Shi, Y.Y., Tong, G.Z., Qiu, Y.F.*, and Ma, Z.Y.* (2017). Nonstructural Protein 4 of Porcine Reproductive and Respiratory Syndrome Virus Modulates Cell Surface Swine Leukocyte Antigen Class I Expression by Downregulating β2-Microglobulin Transcription. Journal of Virology 91(5):e01755-16. 

11, Deng, X.F.#, Wei, J.C.#, Yan, W.J., Wu, Z.C., Shao, D.H., Li, B.B., Liu, K., Wang, X.D., Qiu, Y.F.*, and Ma, Z.Y.* (2016). Tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus. Journal of Genetics and Genomics 43(12):709-712.

12, Qiu, Y.F., Davis, M.J., Dayrit, J.K., Hadd, Z., Meister, D.L., Osterholzer, J.J., Williamson, P.R., and Olszewski, M.A.* (2012). Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice. PLoS ONE 7(10): e47853. 

13, Qiu, Y.F., Shen, Y., Li, X.D., Chan, D., and Ma, Z.Y.* (2008). Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88(MyD88). Developmental and Comparative Immunology 32(12):1522-1530.

14, Qiu, Y.F., Shen, Y., Li, X.D., Liu, Q.W., and Ma, Z.Y.* (2008). Polyclonal antibody to porcine p53 protein: A new tool for studying the p53 pathway in a porcine model. Biochemical and Biophysical Research Communication 377(1): 151-155.

15, Zheng, X.C.#, Zheng, H.#, Tong, W., Li, G.X., Wang, T., Li, L.W., Gao, F., Shan, T.L., Yu, H., Zhou, Y.J., Qiu, Y.F., Ma, Z.Y., and Tong, G.Z.* (2018). Acidity/Alkalinity of Japanese Encephalitis Virus E Protein Residue 138 Alters Neurovirulence in Mice. Journal of Virology 91: e00108-18.

16, Neal, L.M., Qiu, Y.F., Chung, J.H., Xing, E.Z., Cho, W.S., Malachowski, A.N., Sand-Sloat, A.R., Osterholzer, J.J., Maillard, I. and Olszewski, M.A.* (2017). T cell restricted Notch signaling contributes to pulmonary Th1 and Th2 immunity during Cryptococcus neoformans infection. Journal of immunology 199(2): 643-655

17, Liu, K., Qian, Y.J., Jung, Y.S., Zhou, B., Cao, R.B., Shen, T., Shao, D.H., Wei, J.C., Ma, Z.Y., Chen, P.Y.*, Zhu, H.M.*, and Qiu, Y.F. (2017). mosGCTL-7, a C-Type Lectin Protein, Mediates Japanese Encephalitis Virus Infection in Mosquitoes. Journal of Virology 91(10): e01348-16.

18, Eastman, A.J., He, X.M., Qiu, Y.F., Davis, M.J., Vedula, P., Lyons, D.M., Park, Y.D., Hardison, S.E., Malachowski, A.N., Osterholzer, J.J., Wormley, FL Jr, Williamson, P.R., Olszewski, M.A.* (2015). Cryptococcal Heat Shock Protein 70 Homolog Ssa1 Contributes to Pulmonary Expansion of Cryptococcus neoformans during the Afferent Phase of the Immune Response by Promoting Macrophage M2 Polarization. Journal of Immunology 194(12):5999-6010.

19, Davis, M.J., Eastman, A.J., Qiu, Y.F., Gregorka, B., Kozel, T.R., Osterholzer, J.J., Curtis, J.L., Swanson, J.A., and Olszewski, M.A.* (2015). Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal Virulence. Journal of Immunology 194(5): 2219-2231.

20, Davis, M.J.#, Tsang, T.M.#, Qiu, Y.F., Dayrit, J.K., Freij, J.B., Huffnagle, G.B., and Olszewski, M.A.* (2013). Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection. mBio 4(3): e00264-13.

21, Wang, X.D., Deng, X.F., Yan, W.J., Zhu, Z.Q., Shen, Y., Qiu, Y.F., Shi, Z.X., Shao, D.H., Wei, J.C., Xia, X.Z., and Ma, Z.Y.* (2012). Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53. Journal of Biological Chemistry 287(22):18366-75. 

22, Deng, X.F., Shi, Z.X., Li, S.Q., Wang, X.D., Qiu, Y.F., Shao, D.H., Wei, J.C., Tong, G.Z., and Ma, Z.Y. (2011). Characterization of nonstructural protein 3 of a neurovirulent Japanese encephalitis virus strain isolated from a pig. Virology Journal 8:209.

23, Wang, X.D., Shen, Y., Qiu, Y.F., Shi, Z.X., Shao, D.H., Chen, P.J., Tong, G.Z., and Ma, Z.Y.* (2010) The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis. Biochemical and Biophysical Research Communication 395(1): 141-5.

24, Shen, Y., Wang, X.D., Guo, L., Qiu, Y.F., Li, X.D., Yu, H, Xiang, H., Tong, G.Z., and Ma, Z.Y.* (2009) Influenza A virus induces p53 accumulation in a biphasic pattern. Biochemical and Biophysical Research Communication 382(2): 331-5.

25, Li, X.D., Qiu, Y.F., Shen, Y., Ding, C., Liu, P.H., Zhou, J.P., and Ma, Z.Y.* (2008) Splicing together different regions of a gene by modified polymerase chain reaction-based site-directed mutagenesis. Analytical Biochemistry 373(2): 398-400.

26, Ge, F.F., Qiu, Y.F., Yang, Y.W., and Chen, P.Y.* (2007). An hsp70 fusion protein vaccine potentiates the immune response against Japanese encephalitis virus. Archives of virology 152(1):125-135.

27, Ge, F.F., Qiu, Y.F., Gao, X.F., Yang, Y.W., and Chen, P.Y.* (2006). Fusion expression of major antigenic segment of JEV E protein-hsp70 and the identification of domain acting as adjuvant in hsp70. Veterinary immunology and immunopathology 113(3-4):288-96.