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人才队伍

于圣青


研究领域:畜禽细菌性传染病致病机制及其防控技术研究
电话/传真:021-34293461
电子邮件:yus@shvri.ac.cn
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简历(200-500字):
于圣青,女,日本国立山口大学兽医公共卫生学博士、美国国立卫生研究院(NIH)博士后。现任中国农业科学院畜禽细菌性传染病创新团队首席科学家、博士研究生导师、中国农业科学院上海兽医研究所研究员、兽医公共卫生研究室副主任。兼任中国畜牧兽医学会兽医公共卫生学分会常务理事、南京农业大学研究生导师、扬州大学教授。主持“863”、国家自然科学基金面上项目等10多项课题的研究,获得研究经费千万余元。近5年在“Infection and Immunity” 、“Applied and Environmental Microbiology”等国际著名刊物发表SCI收录论文50余篇、获得国家发明专利授权7项。

获奖及荣誉:
1:2015年获得闵行区职工科技创新成果一等奖1项
2:2008年获得人力资源和社会保障部高层次留学人才回国资助1项
3:2008年获得上海市闵行区领军人才称号
4:1998年获得国家留学基金委公派留学资助1项
5:1998年获得“江苏省中青年农业科技骨干”称号
科研获奖:
1:“鸭疫里默氏杆菌毒力基因、诊断技术研究及应用”
   2014年获得中国农业科学院科技进步二等奖,排名第1。
2:“鸡败血霉型体病防治方法的研究”
   2000年获得江苏省科技进步二等奖,排名第2。
3:“新城疫病毒单克隆抗体及强毒感染快速诊断新技术的研究”
   1997年获得农业部科技进步二等奖,排名第3。
4:“抗鸡IgM单克隆抗体的研究及其在鸡新城疫病快速诊断中的应用”
   1996年获得江苏省科技进步四等奖,排名第1。

承担科研项目情况:
1:“863”课题“家禽病毒病基因工程疫苗创制”(2011AA10A209),2011-2015年,1020万元,项目主持人。
2:中国农业科学院科技创新工程资助,250万元/年,2015年-,首席科学家。
3:国家自然科学基金面上项目“鸭疫里默氏杆菌脂多糖的结构分析与分子致病机制研究” (31272591),2013-2016年,80万元,项目主持人。
4:国家自然科学基金面上项目“鸭疫里默氏杆菌LuxS/AI-2型密度感应系统及其对细菌毒力和生物被膜形成的调控” (31072161),2011-2013年,33万元,项目主持人。
5:“973”课题“布鲁氏菌功能基因和蛋白研究”(2010CB530202),2010-2014年,62万元,子课题主持人。
6:“948”项目“转座子信号标签突变技术(STM)的引进及其在牛型布氏杆菌毒力因子筛选中的应用研究”(2012-Z9),2012-2013年,30万元,项目主持人。
7:农业公益性行业科研专项“水禽主要疫病快速诊断与疫苗研制” (201003012), 2010-2014年,300万元,子课题主持人。
8:农业公益性行业科研专项“家禽细菌病研究”(201303044), 2013-2017年,120万元,子课题主持人。
9:公益性行业科研专项“动物源性沙门菌病防控技术研究与示范” (201403054),2014-2018年,120万元,子课题主持人。
10:上海市科技兴农重点攻关项目“鸭疫里默氏杆菌病多价油乳剂灭活疫苗的研制” [沪农科攻字(2009)第5-3号],2009-2012年,30万元,课题主持人。

代表论著:
1. Wang X, Ding C, Wang S, Han X, Yu S*. Whole-genome Sequence Analysis and Genome-wide Virulence Gene Identification of Riemerella anatipestifer Strain Yb2. Appl Environ Microbiol. 2015 May 22. pii: AEM.00828-15. [Epub ahead of print]

2. Hou W, Wang S, Wang X, Han X, Fan H, Cao S, Yue J, Wang Q, Jiang W, Ding C, Yu S*. Development of colloidal gold immunochromatographic strips for detection of Riemerella anatipestifer. PLoS One. 2015 Mar 30;10(3):e0122952. doi: 10.1371/journal.pone.0122952. 

3. Zou J, Wang X, Tian M, Cao S, Hou W, Wang S, Han X, Ding C, Yu S*. The M949_1556 gene plays a role on the bacterial antigenicity and pathogenicity of Riemerella anatipestifer. Vet Microbiol. 2015 May 15;177(1-2):193-200. doi: 10.1016/j.vetmic.2015.03.003. 

4. Wang X, Ding C, Han X, Wang S, Yue J, Hou W, Cao S, Zou J, Yu S*.Complete Genome Sequence of Riemerella anatipestifer Serotype 1 Strain CH3. Genome Announc. 2015 Feb 19;3(1). pii: e01594-14. doi: 10.1128/genomeA.01594-14.

5. Wang S, Dai J, Meng Q, Han X, Han Y, Zhao Y, Yang D, Ding C, Yu S*. DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Front Microbiol. 2014 Nov 7;5:588. doi: 10.3389/fmicb.2014.00588. 

6. Wang X, Ding C, Wang S, Han X, Hou W, Yue J, Zou J, Yu S*. The AS87_04050 gene is involved in bacterial lipopolysaccharide biosynthesis and pathogenicity of Riemerella anatipestifer. PLoS One. 2014 Oct 10;9(10):e109962. doi: 10.1371/journal.pone.0109962. 

7. Cao S, Han X, Ding C, Wang S, Tian M, Wang X, Hou W, Yue J, Wang G, Yu S*. Molecular cloning of the duck mitogen-activated protein kinase 1 (MAPK1) gene and the development of a quantitative real-time PCR assay to detect its expression. Poult Sci. 2014 Sep;93(9):2158-67. doi: 10.3382/ps.2013-03796. 

8. Han Y, Han X, Wang S, Meng Q, Zhang Y, Ding C, Yu S*. The waaL gene is involved in lipopolysaccharide synthesis and plays a role on the bacterial pathogenesis of avian pathogenic Escherichia coli. Vet Microbiol. 2014 Aug 27;172(3-4):486-91. doi: 10.1016/j.vetmic.2014.05.029. 

9. Han X, Tong Y, Tian M, Zhang Y, Sun X, Wang S, Qiu X, Ding C, Yu S*.Enzymatic activity analysis and catalytic essential residues identification of Brucella abortus malate dehydrogenase. Scientific World Journal. 2014;2014:973751. doi: 10.1155/2014/973751.


10. Wang S, Meng Q, Dai J, Han X, Han Y, Ding C, Liu H, Yu S*. Development of an allele-specific PCR assay for simultaneous sero-typing of avian pathogenic Escherichia coli predominant O1, O2, O18 and O78 strains. PLoS One. 2014 May 7;9(5):e96904. doi: 10.1371/journal.pone.0096904. 

11. Tian M, Qu J, Han X, Ding C, Wang S, Peng D, Yu S*. Mechanism of Asp24 upregulation in Brucella abortus rough mutant with a disrupted O-antigen export system and effect of Asp24 in bacterial intracellular survival. Infect Immun. 2014 Jul;82(7):2840-50. doi: 10.1128/IAI.01765-14.

12. Han X, Tong Y, Tian M, Sun X, Wang S, Ding C, Yu S*.Characterization of the immunogenicity and pathogenicity of malate dehydrogenase in Brucella abortus. World J Microbiol Biotechnol. 2014 Jul;30(7):2063-70. doi: 10.1007/s11274-014-1631-2.

13. Han X, Sun X, Shan X, Zhang M, Song J, Tian M, Fan G, Wang S, Tong Y, Ding C, Yu S*. In vivo-induced argininosuccinate lyase plays a role in the replication of Brucella abortus in RAW264.7 cells. Microbiology. 2014 Mar;160(Pt 3):567-75. doi: 10.1099/mic.0.072926-0.

14. Tian M, Qu J, Han X, Zhang M, Ding C, Ding J, Chen G, Yu S*. Microarray-based identification of differentially expressed genes in intracellular Brucella abortus within RAW264.7 cells. PLoS One. 2013 Aug 7;8(8):e67014. doi: 10.1371/journal.pone.0067014. 

15. Zhang M, Han X, Liu H, Tian M, Ding C, Song J, Sun X, Liu Z, Yu S*.
Inactivation of the ABC transporter ATPase gene in Brucella abortus strain 2308 attenuated the virulence of the bacteria. Vet Microbiol. 2013 Jun 28;164(3-4):322-9. doi: 10.1016/j.vetmic.2013.02.017.

16. Liu H, Wang X, Ding C, Han X, Cheng A, Wang S, Yu S*.Development and evaluation of a trivalent Riemerella anatipestifer-inactivated vaccine.
Clin Vaccine Immunol. 2013 May;20(5):691-7. doi: 10.1128/CVI.00768-12. 

17. Han X, Bai H, Liu L, Dong H, Liu R, Song J, Ding C, Qi K, Liu H, Yu S*.The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli. Microb Pathog. 2013 Feb;55:21-7. doi: 10.1016/j.micpath.2012.09.008. 

18. Hu Q, Zhu Y, Tu J, Yin Y, Wang X, Han X, Ding C, Zhang B, Yu S*. Identification of the genes involved in Riemerella anatipestifer biofilm formation by random transposon mutagenesis. PLoS One. 2012;7(6):e39805. doi: 10.1371/journal.pone.0039805. 

19. Hu Q, Ding C, Tu J, Wang X, Han X, Duan Y, Yu S*.Immunoproteomics analysis of whole cell bacterial proteins of Riemerella anatipestifer. Vet Microbiol. 2012 Jun 15;157(3-4):428-38. doi: 10.1016/j.vetmic.2012.01.009. 

20. Han X, Hu Q, Ding S, Chen W, Ding C, He L, Wang X, Ding J, Yu S*. Identification and immunological characteristics of chaperonin GroEL in Riemerella anatipestifer. Appl Microbiol Biotechnol. 2012 Feb;93(3):1197-205. doi: 10.1007/s00253-011-3635-2. 

21. Han X, Ding C, He L, Hu Q, Yu S*.Development of loop-mediated isothermal amplification (LAMP) targeting the GroEL gene for rapid detection of Riemerella anatipestifer. Avian Dis. 2011 Sep;55(3):379-83.

22. Hu Q, Tu J, Han X, Zhu Y, Ding C, Yu S*. Development of multiplex PCR assay for rapid detection of Riemerella anatipestifer, Escherichia coli, and Salmonella enterica simultaneously from ducks. J Microbiol Methods. 2011 Oct;87(1):64-9. doi: 10.1016/j.mimet.2011.07.007. 

23. Han X, Ding C, Chen H, Hu Q, Yu S*. Enzymatic and biological characteristics of enolase in Brucella abortus A19. Mol Biol Rep. 2012 Mar;39(3):2705-11. doi: 10.1007/s11033-011-1025-6. 

24. Hu Q, Han X, Zhou X, Ding C, Zhu Y, Yu S*. OmpA is a virulence factor of Riemerella anatipestifer. Vet Microbiol. 2011 Jun 2;150(3-4):278-83. doi: 10.1016/j.vetmic.2011.01.022. 

25. Hu Q, Han X, Zhou X, Ding S, Ding C, Yu S*. Characterization of biofilm formation by Riemerella anatipestifer. Vet Microbiol. 2010 Aug 26;144(3-4):429-36. doi: 10.1016/j.vetmic.2010.02.023. 

26. Yu S, Xie H, Datta A, Naidu N, Gu XX. Galactose residues on the lipooligosaccharide of Moraxella catarrhalis 26404 form the epitope recognized by the bactericidal antiserum from conjugate vaccination. Infect Immun. 2008 Sep;76(9):4251-8. doi: 10.1128/IAI.01570-07.

27. Yu S, Gu XX. Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis. Infect Immun. 2007 Jun;75(6):2974-80.

28. Yu S, Gu XX. Synthesis and characterization of lipooligosaccharide-based conjugate vaccines for serotype B Moraxella catarrhalis. Infect Immun. 2005 May;73(5):2790-6.

29. Yu S, Shinya K, Otsuki K, Ito H, Ito T. Isolation of myxoviruses from migratory waterfowls in San-in district, western Japan in winters of 1997-2000. J Vet Med Sci. 2002 Nov;64(11):1049-52.

30. Yu S, Kishida N, Ito H, Kida H, Otsuki K, Kawaoka Y, Ito T. Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens. Virology. 2002 Sep 30;301(2):206-11.