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人才队伍

程国锋

研究领域:寄生虫分子生物学
电话/传真:021-34293659
电子邮件:chenggfeng@shvri.ac.cn

简历(200-500字):
程国锋,博士,中国农科院上海兽医研究所研究员,动物血吸虫病创新团队首席专家,博士研究生导师,国际期刊Journal of Bioanalysis and Biomedicine编委成员,全国动物卫生标准化技术委员会委员,中国畜牧兽医学会兽医公共卫生学分会理事等。
主要针对寄生虫学为研究对象,研究领域涉及病原生物学、生化与分子遗传学和药学等。工作中有所发现和突破。目前,在Advanced Drug Delivery Reviews, Journal of Biological Chemistry,Journal of Proteome Research,Proteomics,J ournal of Proteomics,Parasitology等国内外期刊发表论文近50篇,论文被国内外同行引用400余次。相关研究获得上海明治生命科学奖、国家百篇优秀博士论文提名奖、上海市科技进步奖二等奖(第三完成人)和中国农业科学院科学技术成果奖二等奖(第三完成人)等奖励。

获奖及荣誉:
2006年获上海明治生命科学奖科学奖;
2007年获全国百篇优秀博士论文提名;
2008年获中国农业科学院科学技术成果奖二等奖(第三完成人);
2008年获上海市科技进步奖二等奖(第三完成人);
2009年获上海市领军人才后备队培养计划(闵行领军人才);
2009年获上海市人才发展资金资助;
2010年获上海市浦江人才称号并获资助;
2013年获中国农业科学院“金龙鱼”杰出青年称号。

承担科研项目情况:
国家自然科学基金;
上海市浦江人才计划;
上海市非政府间国际合作项目;
上海市人才发展资金;
留学回国人才科研启动基金;
中央级科研院所基本科研业务费等。


代表论著:
主要论文发表:
A.英文国际期刊 (*Corresponding author)
(1) Zhu L, Dao J, Du X, Li H, Lu K, Liu J, Cheng G*. Altered levels of circulating miRNAs are associated Schistosoma japonicum infection in mice. Parasit Vectors. 2015 Apr 1;8:196. doi: 10.1186/s13071-015-0806-5.
(2) Zhu L, Liu J, Cheng G*. Role of microRNAs in schistosomes and schistosomiasis. Front Cell Infect Microbiol. 2014 Nov 11;4:165. doi: 10.3389/fcimb.2014.00165.
(3) Cheng G*. Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy. Adv Drug Deliv Rev. 2015 Jan;81:75-93. doi: 10.1016/j.addr.2014.09.001. (2014 SCI IF=12.707).
(4) Hu, Zhu l, Luo R, Dao J, Zhao J, Shi Y, Li H, Lu K, Feng X, Lin J, Liu J, Cheng G*. Evaluation of protective immune response in mice by vaccination the recombinant adenovirus for expressing Schistosoma japonicum inhibitor apoptosis protein. Parasitology Research. 2014, 113(11):4261-9. doi: 10.1007/s00436-014-4104-5. (2014 SCI IF=2.327).
(5) Dao J, Zhu L, Luo R, Hu C, Wang Y, Li H, Lu K, Liu J, Lin J, Cheng G*. Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum. Parasitology Research. 2014, 113(11):4065-71. (2014 SCI IF=2.327).
(6) He X, Jing Z*, Cheng G*. MicroRNAs: new regulators of Toll-like receptor signalling pathways. Biomed Res Int. 2014: 945169. doi: 10.1155/2014/945169. (2014 SCI IF=2.706).
(7) Cheng G*, Lin J. Parasitic helminths: a useful resource for inflammatory and autoimmune therapy. J Bioanal Biomed. 2013, 5: 075-076. doi:10.4172/1948-593X.1000084.
(8) Cheng G*, Luo R, Hu C, Cao J, Jin Y. Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum. Parasitology. 2013 Aug 13:1-11. (2011 SCI IF=2.96).
(9) Cheng G*, Luo R, Hu C, Lin J, Bai Z, Zhang B, Wang H. TiO2-based phosphoproteomic analysis of schistosomes: characterization of phosphorylated proteins in the different stages and sex of Schistosoma japonicum. J Proteome Res. 2013 Feb 1;12(2):729-42. (2011 SCI IF=5.11).
(10) Luo R, Zhou C, Shi Y, Zhao J, Cheng G*. Molecular characterization of a cytokine-induced apoptosis inhibitor from Schistosoma japonicum. Parasitol Res. 2012 Dec;111(6):2317-24. (2011 SCI IF=2.149).
(11) Cheng G* and Jin YX. microRNAs: Potentially Important Regulators for Schistosome Development and Therapeutic Targets against Schistosomiasis. Parasitology. 2012 Apr;139(5):669-79. (2011 SCI IF=2.96).
(12) Luo R, Zhou C, Lin J, Yang D, Shi Y, Cheng G*. Identification of in vivo protein phosphorylation sites in human pathogen Schistosoma japonicum by a phosphoproteomic approach. J Proteomics. 2012, 75(3):868-77. (2010 SCI IF=5.047)
(13) Chen J, Yang Y, Guo S, Peng J, Liu Z, Li J, Lin J*, Cheng G*. Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum. Parasitol Res. 2010;107(4):889-99. (2010 SCI IF=1.812)
(14) Peng J, Yang Y, Feng X, Cheng G*, Lin J*. Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum. Parasitol Res. 2010;106(4):967-76. (2010 SCI IF=1.812)
(15) Cheng G, Fu Z, Lin J, Shi Y, Zhou Y, Jin Y, Cai Y. In vitro and in vivo evaluation of small interference RNA-mediated gynaecophoral canal protein silencing in Schistosoma japonicum. J Gene Med. 2009;11(5):412-21. (2009 SCI IF=2.986)
(16) Cheng G, Zhu L, Mahato RI. Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. Mol Pharm. 2008;5(6):1093-102. (2008 SCI IF=4.565)
(17) Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm Res. 2008;25(1):72-86. (2008 SCI IF=4.024)
(18) Cheng G, Davis RE. An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol. 2007;155(2):167-71. (2007 SCI IF=2.896) 【Selected by Faculty 1000 biology】
(19) Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007;153(2):95-106. (2007 SCI IF=2.896)
(20) Cheng G, Cohen L, Ndegwa D, Davis RE. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006 13;281(2):733-43. (2006 SCI IF=5.808)
(21) Cheng GF, Lin JJ, Shi Y, Jin YX, Fu ZQ, Jin YM, Zhou YC, Cai YM. Dose-dependent inhibition of gynecophoral canal protein gene expression in vitro in the schistosome (Schistosoma japonicum) by RNA interference. Acta Biochim Biophys Sin. 2005;37(6):386-90. (2005 SCI IF=0.505)
(22) Cheng GF, Lin JJ, Feng XG, Fu ZQ, Jin YM, Yuan CX, Zhou YC, Cai YM. Proteomic analysis of differentially expressed proteins between the male and female worm of Schistosoma japonicum after pairing. Proteomics. 2005;5(2):511-21. (2005 SCI IF=6.08)

B. 编著
(23) Cheng G, Danquah M and Mahato RI (2009) MicroRNAs as therapeutic targets for cancer. In: Lu Y and Mahato RI (eds) Pharmaceutical Perspectives of Cancer Therapeutics (ISBN: 978-1-4419-0130-9) Springer, New York, NY. pp441-474.

C. 国内期刊(*通讯作者)
(24) 张亮, 程国锋, 付志强, 金亚美, 冯新港, 苑纯秀, 蔡幼民. 血吸虫新抗原基因SjMF4的克隆、表达及功能分析. 生物化学与生物物理学报, 2003,35(12):1099-1104. (2003 SCI IF=0.524)
(25) 胡超,罗荣,刀金威,王宇清,赵江平,陆 珂,李浩,刘金明,程国锋. 日本血吸虫重组IAP蛋白的免疫保护效果评估. 中国动物传染病学报.2014, 22(3):34-41.
(26) 罗荣,郭素霞,石耀军,程国锋*.日本血吸虫4 个基因启动子相关序列的克隆和初步研究. 中国血吸虫病防治杂志. 2013,25(3):246-249.
(27) 罗荣,赵江平,胡超,程国锋*. 干扰日本血吸虫凋亡抑制因子最佳siRNAs分子的筛选. 中国人兽共患病学报.2013,29(9):53-56.
(28) 赵江平,刘金明,程国锋*. miRNAs在日本血吸虫不同发育时期表达情况的研究. 中国动物传染病学报. 2013, 21(4): 29-32.
(29) 程国锋*,卫大群,罗荣,石耀军. 表达日本血吸虫凋亡抑制因子的重组腺病毒的构建和鉴定. 中国动物传染病学报. 2012, 20(3): 26-30.
(30) 周春景,罗 荣,石耀军,赵江平,程国锋*.日本血吸虫GSK3蛋白编码cDNA的克隆、表达及其重组蛋白的免疫保护研究. 中国动物传染病学报. 2012, 20(4): 52-57.
(31) 罗荣,周春景,石耀军,赵江平,程国锋*.日本血吸虫WD40信号蛋白的原核表达.中国动物传染病学报. 2012, 20(3): 50-54.
(32) 周春景,罗荣,石耀军,丁硕,杨德浩,程国锋*. 编码日本血吸虫Akt蛋白的cDNA克隆及原核表达. 中国动物传染病学报. 2011,19(4): 62-67.
(33) 罗荣,于金波,周春景,杨德浩,程国锋*. 编码日本血吸虫CIAPIN1 cDNA 的克隆及其重组蛋白的原核表达. 中国动物传染病学报. 2011,19(2): 57-61.
(34) 杨燕萍, 郭素霞,  陈晶, 林矫矫, 刘宗平, 程国锋*. 编码日本血吸虫Argonaute蛋白的全长cDNA获得及其初步研究. 中国人兽共患病学报.2010(26):830-834.
(35) 陈晶, 郭素霞, 杨燕萍, 刘金明, 林矫矫, 李家奎, 程国锋*. 编码日本血吸虫Argonaute 3蛋白全长cDNA的获得及初步研究. 中国血吸虫病防治杂志.2010(22):310-314.
(36) 何小兵,房永祥,贾怀杰,陈国华,曾爽,景志忠*,程国锋*. Toll样受体7介导的抗病毒天然免疫反应的研究进展. 中国兽医科技. 2010 ,40 (6) :645-649.