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人才队伍

林矫矫

研究领域:寄生虫学与寄生虫病防控
联系电话和传真: 021-34293440 (Office)
                          021-54081818 (Fax)
                           13818059455 (Moible)
电子邮箱:jjlin@shvri.ac.cn
通讯地址:上海市闵行区紫月路518号
邮政编码:200241

个人简介:
中国农科院上海兽医研究所研究员、博士、博士生导师。自1982年2月起,主要在中国农科院上海兽医研究所从事日本血吸虫功能基因组学和蛋白质组学、血吸虫与宿主相互作用机制、家畜血吸虫病免疫预防、诊断和综合防治等研究,期间分别于1987年、1992年和1994年先后到美国宾夕法尼亚大学医学院、英国伦敦大学卫生和热带医学院、美国哥伦比亚大学医学院从事血吸虫免疫学和分子生物学及肿瘤分子生物学研究近6年。先后主持国家“973”课题、“863”计划、国家科技支撑计划、公益性行业(农业)科研专项、国家自然科学基金等国家和省部级科研项目36项。获省部级科研成果10项(其中7项为第一完成人,2项为第二完成人),国家发明专利证书16个,实用专利证书3个,农业部新兽药证书1项,农业转基因生物安全证书4项,计算机软件著作登记证书2项。主编和参编科技著作17部。在《Mol. Cell. Proteomics》等国内外学术期刊上发表科研论文325篇,其中被SCI收录的92篇。被评为上海市领军人才、农业部有突出贡献的中青年专家和中国农业科学院学科带头人。享受政府特殊津贴。目前兼任农业部动物血吸虫病专家咨询委员会主任委员、农业部动物寄生虫学重点实验室主任、卫生部疾病预防控制专家委员会血吸虫病和寄生虫病分委员会委员,中国畜牧兽医学会兽医寄生虫分会副理事长、上海市寄生虫学会副理事长、上海师范大学兼职教授、《中国血吸虫病防治杂志》副主编等职。


获奖及荣誉:
获奖成果:
1、家畜日本血吸虫病控制技术,2011年获中华农业科技奖二等奖,第一完成人;
2、日本血吸虫疫苗候选抗原基因筛选及保护效果,2008年获上海市科技进步二等奖,第一完成人;
3、日本血吸虫生长发育相关基因的筛选、分析及功能研究,2008年获中国农业科学院科学技术成果二等奖,第一完成人;
4、东方田鼠实验动物化和抗血吸虫病机制研究,2006年获上海市科学技术进步三等奖,2007年获中国农业科学院科学技术成果二等奖,第一完成人;
5、重流行区动物血吸虫病疫情控制技术研究,2002年获中国农业科学院科学技术成果一等奖;2003年获上海市科学技术进步二等奖,第二完成人;
6、日本血吸虫(中国大陆株)抗原基因的克隆和表达及动物保护效果评估,2001年获上海市科学技术进步二等奖和中国农业科学院科学技术成果一等奖,第一完成人;
7、江湖洲滩地区日本血吸虫病流行病学调查和防治对策,1993年获农业部科学技术进步三等奖,第十五完成人。
荣誉:
2001年获卫生部、农业部、水利部授予的“全国血吸虫病防治先进个人”光荣称号;
2009年获卫生部、农业部、水利部、林业局授予的“全国血吸虫病防治先进个人”光荣称号;
2005年获上海市颁发的“消灭血吸虫病20周年纪念荣誉证书”;
上海市领军人才;
农业部有突出贡献的中青年专家;
享受政府特殊津贴。
目前承担的科研项目:
1、日本血吸虫凋亡现象观察与分析,81271871,国家自然科学基金;
2、不同宿主来源日本血吸虫的分子标识筛选,2012ZX10004220,国家科技重大专项项目;
3、Adjuvant and Dose Optimization of Paramyosin based Vaccines for Schistosmiasis, R21AI097963,美国NIH项目;
4.日本血吸虫体被表面蛋白质组研究,31172315,国家自然科学基金;
5.动物血吸虫病疫情监测与防治,农业部动物疫情监测与防治专项。

代表论著:
著作:
1、李长友,林矫矫主编:《农业血防五十年图册》,中国农业科技出版社,2012年
2、李长友,林矫矫主编:农业血防五十年,中国农业科学技术出版社,2008
3、徐百万,林矫矫主编:农业综合治理防控血吸虫病技术导则,中国农业科学技术出版社,2007
4、徐百万主编,林矫矫、李万有副主编:中国农业血防(1990-2000),中国农业科技出版社,2004
论文:
1.Hong, Y., Peng, J.B., Jiang, W.B., Fu, Z.Q., Liu, J.M., Shi, Y.J., Li, X.R*, Lin, J.J. *. Proteomic Analysis of Schistosoma japonicum Schistosomulum Proteins that are Differentially Expressed Among Hosts Differing in Their Susceptibility to the Infection. Mol Cell Proteomics, 2011, 10(8): M110006098
2.Zhang, M., Hong, Y., Han, Y., Han, H., Peng, J., Qiu, C., Yang, J., Lu, K., Fu, Z. *, Lin, J*.,  Proteomic Analysis of Tegument-Exposed Proteins of Female and Male Schistosoma japonicum Worms. J Proteome Res,2013,12(11), 5260-70
3.Zhang, Min,Fu, Zhiqiang,Li, Changjian,Han, Yanhui,Cao, Xiaodan,Han, Hongxiao,Liu, Yantao,Lu,Ke,Hong, Yang*,Lin, Jiaojiao*,Screening Diagnostic Candidates for Schistosomiasis from Tegument Proteins of Adult Schistosoma japonicum Using an Immunoproteomic Approach.,PLoS Negl Trop Dis,2015,9(2):e0003454-e0003454
4.Hongxiao Han, Jinbiao Peng, Yanhui Han, Min Zhang, Yang Hong, Zhiqiang Fu, Jianmei Yang,Jianping Tao*, Jiaojiao Lin*,Differential Expression of microRNAs in the Non-Permissive Schistosome Host Microtus fortis underSchistosome Infection,PLoS One, 2013, 8(12): e85080.
5. Yanian Xiong, Min Zhang, Yang Hong, Meimei Wei, Dezhou Ai, Peipei Meng, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jianmei Yang, Jiaojiao Lin*. Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. PLoS One, 2013, 8 (6): e66396.
6.Jianmei Yang, Yang Hong, Chunxiu Yuan, Zhiqiang Fu, Yaojun Shi, Min Zhang, Liuhong Shen, Yanhui Han, Chuangang Zhu, Hao Li, Ke Lu, Jinming Liu, Xingang Feng, Jiaojiao Lin*. Microarray Analysis of Gene Expression Profiles of Schistosoma japonicum Derived from Less-Susceptible Host Water Buffalo and Susceptible Host Goat. PLoS One, 2013, 8 (8): e70367.
7.Hongxiao Han, Jinbiao Peng, Yang Hong, Min Zhang, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jinjun Xu, Jianping Tao*, Jiaojiao Lin*. Comparison of the differential expression miRNAs in Wistar rats before and 10 days after S. japonicum infection. Parasit Vectors, 2013, 6(1): 120.
8.C. Qiu, S. Liu*, Y. Hong, Z. Fu, M. Wei, D. Ai, J. Lin*. Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Parasit Vectors, 2012, 5: 172.
9.J. Yang, X. Feng, Z. Fu, C. Yuan, Y. Hong, Y. Shi, M. Zhang, J. Liu, H. Li, K. Lu, J. Lin*, Ultrastructural Observation and Gene Expression Profiling of Schistosoma japonicum Derived from Two Natural Reservoir Hosts, Water Buffalo and Yellow Cattle. PLoS One, 2012, 7 (10): e47660.
10.Peng, J.B., Gobert, G. N., Hong, Y., Jiang, W.B., Han, H.X., McManus, D.P., Wang, X.Z., Liu, J.M., Fu, Z.Q., Shi, Y.J., Lin, J.J*.. Apoptosis Governs the Elimination of Schistosoma japonicum from the Non-Permissive Host Microtus fortis. PLoS One, 2011, 6(6): e21109.
11.Peng, J.B., Han, H.X., Gobert, G. N., Hong, Y., Jiang, W.B., Wang, X.Z., Fu, Z.Q., Liu, J.M., Shi, Y.J., Lin, J.J*.. Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice. Parasit Vectors, 2011, 4(1): 155.
12.Jiang Weibin, Hong Yang, Peng Jinbiao, Fu Zhiqiang, Feng Xingang, Liu Jinming, Shi Yaojun, Lin Jiaojiao*. Study on differences in the pathology, T cell subsets and gene expression in susceptible and non-susceptible hosts infected with Schistosoma japonicum, PLoS One, 2010, 5(10): e13494
13.Su ZZ, Madireddi MT, Lin JJ, Young CS, Kitada S, Reed JC, Goldstein NI, Fisher PB. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14400-5.
14.Lin JJ, Jiang H, Fisher PB. Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene. Gene. 1998 Jan 30;207(2):105-10.  
15.Jiang H, Lin JJ, Tao J, Fisher PB.Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta. Oncogene. 1997 Jan 30;14(4):473-80.
16.Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CS, Fisher PB.Proc The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9160-5.                       
17.Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene. 1995 ,11(12):2477-86.  
18.S.Micheal Phillips,JiaoJiao Lin,Nabil Galal,Amars S.tung,Gerald P.Linette and Peter J.Perrin: Resistance in murine schistosomiasis is contigent on activated IL-2 receptor-bearing L3T4+lymphocytes,negatively regulated by lyt-2+ cells, and uninfluenced by the presence of Il-4,J.Immunology, 1991,146:1335-1340                        
19.Phillips SM,Lin JJ,Walker DJ Linette GP,Fathelbab NG,Perrin PJ: The regulation of resistance to schistosoma mansoni by auto-anti-idiotypic immunity,II.Global qualitative and quantitative regulation,J.Immunity, 1990,144:4005-4010           
20.S.Micheal Phillips,JiaoJiao Lin,Nabil Galal,J Gerald P.Linette ,Walker and Peter J.Perrin,The regulation of resistance to schistosoma mansoni by auto-anti-idiotypic immunity:III An analysis of effects on epitopic regulation,idiotypic expression and anti-idiotypic reactive at the clonal level,J Immunology,1990,145:2272-2281