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人才队伍

龚海燕


研究领域:动物寄生虫及其分子生物学
电话/传真:021-34293411
电子邮件:gonghaiyan@shvri.ac.cn
更多信息:

简历(200-500字):
教育经历:
2006/04-2009/03   日本带广畜产大学,国立原虫病研究中心,博士,导师:玄学南
1999/09-2002/07   西南农业大学, 动物医学院,硕士,导师:彭远义
1995/09-1999/07   西南农业大学, 动物医学院,学士
工作经历:
2012/10 始        中国农业科学院上海兽医研究所, 寄生虫研究室,副研究员
2009/03-2012/09   日本东京大学,兽医学部,博士后
2005/10-2006/03   日本带广畜产大学,国立原虫病研究中心,助理研究员
2005/08-2005/09   中国农业科学院上海家畜寄生虫病研究所,寄生虫研究室,助理研究员
2002/08-2005/07   中国农业科学院上海家畜寄生虫病研究所,寄生虫研究室,研究实习员

获奖及荣誉:
获奖情况:以论文“镰形扇头蜱-新基因的分离、克隆、表达和抗蜱免疫保护作用”获得2005年度中国农学会优秀论文中文学术类二等奖。2012年度获得日本第153次日本兽医学术集会日本兽医寄生虫学会奖励赏。

承担科研项目情况:
1. miRNA与长角血蜱唾液腺蛋白关系的研究,留学回国人员科研启动基金,2015.1-2016.12,3.5万,主持。
2. 基于RNA结合蛋白免疫沉淀技术(RIP)的miRNAs靶基因的筛选与功能分析,中央级公益性科研院所基本科研业务费专项资金项目,2015.1-2017.12,30万,主持。
3. 牛羊重要寄生虫致病机制的分子基础,2015CB150300,科技部973项目,2015.1-2019.12,参加。 
4. A new trial to use the retrovirus-mediated expression cloning to screen the receptor on the host cell for the binding of Toxoplasma gondii。日本学术振兴会项目Japan Society for the Promotion of Science (JSPS),2010.4-2012.3, 主持。

代表性著作:
1.Gong H, Qin S, Wan X, Zhang H, Zhou Y, Cao J, Xuan X, Suzuki H, Zhou J. Immunoglobulin G binding protein (IGBP) from Rhipicephalus haemaphysaloides: identification, expression, and binding specificity. Parasitol Res. 2014,113,4387-4395.
2.Gong H, Kobayashi K, Sugi T, Takemae H, Ishiwa A, Recuenco FC, Murakoshi F, Xuan X, Horimoto T, Akashi H, Kato K. Characterization and binding analysis of a microneme adhesive repeat domain-containing protein from Toxoplasma gondii. Parasitol Int. 2013 Dec 18. pii: S1383-5769(13)00207-9. doi: 10.1016/j.parint.2013.12.006.
3.Gong H, Kobayashi K, Sugi T, Takemae H, Kurokawa H, Horimoto T, Akashi H, Kato K. A novel PAN/apple domain-containing protein from Toxoplasma gondii: characterization and receptor identification.2012, PloS one 7(1): e30169, IF: 4.41).
4.Gong H, Umemiya R, Zhou J, Liao M, Zhang H, Jia H, Nishikawa Y, Xuan X, Fujisaki K. Blocking the secretion of saliva by silencing HlYkt6 gene in the tick Haemaphysalis longicornis. Insect Biochem Mol Biol.2009 (5-6), 39: 372-381(IF:4.018 ).
5.Gong H, Liao M, Zhou J, Hatta T, Huang P, Zhang G, Kanuka H, Nishikawa Y, Xuan X, Fujisaki K. Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis.Vet Parasitol. 2008 Feb 14;151(2-4):268-278 (IF:2.33 ).
6.Gong H, Zhou J, Liao M, Hatta T, Harnnoi T, Umemiya R, Inoue N, Xuan X, Fujisaki K. Characterization of a carboxypeptidase inhibitor from the tick Haemaphysalis longicornis. J Insect Physiol. 2007 Oct;53 (10):1079-1087 (IF:2.31 ). 
7.龚海燕,镰形扇头蜱中两个新基因的分离、克隆与序列分析。中国兽医学报,2006,26 (2):155-157,168。
8.龚海燕,周金林。蜱对宿主免疫调节作用的研究进展。动物医学进展,2005,26(4):34-38。
9.龚海燕,周金林,周勇志,向飞宇,丘玉涛。镰形扇头蜱―新基因的分离、克隆、表达和抗蜱免疫保护作用,中国兽医寄生虫病,2005,13(3):1-5。
10.龚海燕,周金林,周勇志,张维谊。镰形扇头蜱半饱血雌蜱cDNA文库的构建。中国人兽共患病学报,2004,20(6):485-488。
11.龚海燕,彭远义。牛白血病病毒感染的免疫学研究进展。畜牧与兽医,2002,34(6)41-43。
12.龚海燕,彭远义。鸡传染性腺胃病(暂定名)的研究进展,中国动物检疫。2001,18(5):45-46。
13.Li C, Cao J, Zhou Y, Zhang H, Gong H, Zhou J*. The midgut bacterial flora of laboratory-reared hard ticks, Haemaphysalis longicornis, Hyalomma asiaticum, and Rhipicephalus haemaphysaloides. Journal of Integrative Agriculture, 2095-3119, 2014, 13(8): 1766-1771.
14.Li Y, Luo Y, Cao S, Terkawi MA, Lan DT, Long PH, Yu L, Zhou M, Gong H, Zhang H, Zhou J, Yokoyama N, Suzuki H, Xuan X. Molecular and seroepidemiological survey of Babesia bovis and Babesia bigemina infections in cattle and water buffaloes in the central region of Vietnam. Tropical Biomedicine. 31(3): 406–413, 2014.
15.Recuenco FC, Kobayashi K, Ishiwa A, Enomoto-Rogers Y, Fundador NG, Sugi T, Takemae H, Iwanaga T, Murakoshi F, Gong H, Inomata A, Horimoto T, Iwata T, Kato K. Gellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro. Sci Rep. 2014 Apr 17;4:4723. doi: 10.1038/srep04723.
16.Takemae H, Sugi T, Kobayashi K, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Iwanaga T, Inomata A, Horimoto T, Akashi H, Kato K.Characterization of the interaction between Toxoplasma gondii rhoptry neck protein 4 and host cellular β-tubulin. Sci Rep. 2013 Nov 12;3:3199. doi: 10.1038/srep03199.
17.Ishiwa A, Kobayashi K, Takemae H, Sugi T, Gong H, Recuenco FC, Murakoshi F, Inomata A, Horimoto T, Kato K.Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii. Parasitol Res. 2013 Dec;112(12):4169-76. doi: 10.1007/s00436-013-3608-8. Epub 2013 Oct 6.
18.Kobayashi K, Takano R, Takemae H, Sugi T, Ishiwa A, Gong H, Recuenco FC, Iwanaga T, Horimoto T, Akashi H, Kato K. Analyses of Interactions Between Heparin and the Apical Surface Proteins of Plasmodium falciparum. Sci Rep. 2013 Nov 11;3:3178. doi: 10.1038/srep03178.
19.Iwanaga T, Sugi T, Kobayashi K, Takemae H, Gong H, Ishiwa A, Murakoshi F, Recuenco FC, Horimoto T, Akashi H, Kato K. Characterization of Plasmodium falciparum cdc2-related kinase and the effects of a CDK inhibitor on the parasites in erythrocytic schizogony. Parasitol Int. 2013 Oct;62(5):423-30. doi: 10.1016/j.parint.2013.05.003. Epub 2013 May 18.
20.Sugi T, Kato K, Kobayashi K, Takemae H, Gong H, Ishiwa A, Murakoshi F, Recuenco FC, Iwanaga T, Horimoto T, Akashi H, Kato K. Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1. Int J Parasitol: Drugs and Drug Resistance. 2013, 3: 93-101.
21.Zhou Y, Zhang H, Cao J, Gong H, Zhou J. Isolation and genotyping of Toxoplasma gondii from domestic rabbits in China to reveal the prevalence of type III strains. Vet Parasitol. 2012 Dec 5. pii: S0304-4017.
22.Kurokawa H, Kato K, Iwanaga T, Sugi T, Sudo A, Kobayashi K, Gong H, Takemae H, Recuenco FC, Horimoto T, Akashi H. Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. PLoS One. 2011;6(7):e22492.
23.Sugi T, Kato K, Kobayashi K, Kurokawa H, Takemae H, Gong H, Recuenco FC, Iwanaga T, Horimoto T, Akashi H. 1NM-PP1 treatment of mice infected with Toxoplasma gondii. J Vet Med Sci. 2011 Oct;73(10):1377-1379.
24.Sugi T, Kato K, Kobayashi K, Watanabe S, Kurokawa H, Gong H, Pandey K, Takemae H, Akashi H. Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.Eukaryot Cell. 2010 Apr;9(4):667-670. 
25.Kobayashi K, Kato K, Sugi T, Takemae H, Pandey K, Gong H, Tohya Y, Akashi H. Plasmodium falciparum BAEBL binds to heparan sulfate proteoglycans on the human erythrocyte surface. J Biol Chem. 2010 Jan 15;285(3):1716-1725. 
26.Zhou J, Liao M, Gong H, Xuan X, Fujisaki K. Characterization of Hlcyst-3 as a member of cystatins from the tick Haemaphysalis longicornis. Exp Appl Acarol. 2010 Aug;51(4):327-333.
27.Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K. Characterization of an intracellular cystatin homolog from the tick Haemaphysalis longicornis. Vet Parasitol. 2009 Mar 9;160(1-2):180-183.
28.Liao M, Zhou J, Gong H, Boldbaatar D, Shirafuji R, Battur B, Nishikawa Y, Fujisaki K. Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis. J Insect Physiol. 2009 Feb;55(2):164-173.
29.Liao M, Boldbaatar D, Gong H, Huang P, Umemiya R, Harnnoi T, Zhou J, Tanaka T, Suzuki H, Xuan X, Fujisaki K. Functional analysis of protein disulfide isomerases in blood feeding, viability and oocyte development in Haemaphysalis longicornis ticks. Insect Biochem Mol Biol. 2008 Mar;38(3):285-295.
30.Hatta T, Umemiya R, Liao M, Gong H, Harnnoi T, Tanaka M, Miyoshi T, Boldbaatar D, Battsetseg B, Zhou J, Xuan X, Tsuji N, Taylor D, Fujisaki K. RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis. Parasitol Res. 2007 Mar;100(4):847-854.
31.Liao M, Hatta T, Umemiya R, Huang P, Jia H, Gong H, Zhou J, Nishikawa Y, Xuan X, Fujisaki K. Identification of three protein disulfide isomerase members from Haemaphysalis longicornis tick.Insect Biochem Mol Biol. 2007 Jul;37(7):641-654.
32.Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K. Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. Peptides. 2007 Jun;28(6):1304-1310.
33.Zhou J, Gong H, Zhou Y, Xuan X, Fujisaki K. Identification of a glycine-rich protein from the tick Rhipicephalus haemaphysaloides and evaluation of its vaccine potential against tick feeding. Parasitol Res. 2006 Dec;100(1):77-84.
34.张冰炳 龚海燕,周勇志  曹杰 张厚双 周金林. 亚洲璃眼蜱唾液腺多肽Ha-11的鉴定、表达和生物学功能的初步研究, 中国动物传染病学报. 22(3): 48-52.
35.王玉霞,周勇志,龚海燕,程天印,周金林。亚洲璃眼蜱P27基因的克隆和表达模式分析,畜牧兽医学报,2008,39(2):201-205。
36.向飞宇,周勇志,龚海燕,周金林。镰形扇头蜱组胺结合蛋白全长基因的克隆与分析,中国兽医学报,2008,28(3):257-260。
37.柴国祚,周金林,沈杰,周勇志,向飞宇,龚海燕,马腾。镰形扇头蜱金属蛋白酶基因全长的克隆和序列分析,中国预防兽医学报,2007,29(7):519-523。
38.向飞宇,周金林,周勇志,龚海燕,沈杰。镰形扇头蜱唾液腺抑制消减杂交文库的构建和分析,中国农业科学,2006,39(11):2347-2353。
39.王玉霞,周金林,周勇志,龚海燕,向飞宇,程天印,刘毅。亚洲璃眼蜱差异表达新基因P18的克隆和鉴定,中国预防兽医学报,2006,28(4):396-400。
40.邱玉涛,龚海燕,袁静。猪内源性逆转录病毒对异种组织器官移植影响的研究进展,动物医学进展,2006,27(2):41-45。
41.周勇志,周金林,沈杰,龚海燕,向飞宇,黄兵。伊氏锥虫、马媾疫锥虫、布氏锥虫、刚果锥虫的18S rDNA部分序列测定与系统发育关系,中国预防兽医学报,2006,28(2):178-180。
42.陈灵芝,周金林,李培英 , 周勇志,龚海燕。镰形扇头蜱半胱氨酸蛋白酶基因的克隆与表达及表达产物免疫保护性分析,中国人兽共患病杂志,2005,10:871-874。
43.白霞,周金林,程天印,周勇志,龚海燕。微小牛蜱一个抗菌多肽编码基因的克隆和表达, 中国预防兽医学报,2005,27(2):134-138。
44.张维谊,周金林,龚海燕,周勇志,黄维义。镰形扇头蜱唾液腺cDNA文库的构建.中国兽医学报,2004,24(5):445-447。
45.周金林,周勇志,龚海燕等。我国长角血蜱孤雌生殖种群的发现和生物学特性的研究。中国媒介生物学及控制杂志,2004,15(3):173-174。
46.陈灵芝,周金林,周勇志,龚海燕,李培英。镰形扇头蜱两个组织蛋白酶L-样半胱氨酸蛋白酶新基因的克隆与序列分析。生物工程学报,2004,20(2):203-208。
47.周勇志,周金林,龚海燕,曹杰。四种硬蜱的实验室人工饲养和部分生物学特性的观察[J].中国兽医寄生虫病,2003,11(2):23-24。