Dr. Chan Ding                                                             Deputy Director, Ph.D, Professor   Chief Scientist of the waterfowl viral diseases research team. Shanghai Veterinary Research Institute,  Chinese Academy of Agricultural Sciences.  Address: 518 Ziyue Road ,Shanghai City, China.  Post code: 200241 Tel:(+86)21-34293441 E-mail: shoveldeen@shvri.ac.cn     Web site: www.shvri.ac.cn           Education 1978.9 – 1982.7:  BS, Major in Veterinary Science, Yangzhou University, China 1987.9 – 1990.7: MS, Major in Microbiology and Immunology Research, Nanjing Agricultural University, China     1999.4-2003.3    ph.D, Major in Microbiology , Yamaguchi University, Japan.           Research area      He is chief scientist of waterfowl viral diseases research team of  CAAS. His main research fields are include  Newcastle disease virus, Mycoplasma. G and Duck viral hepatitis. Such as phylogenetic analysis on NDV fields in China, especially on wild bird isolates. Reverse genetics on Newcastle disease virus for vaccine improvement. Study on evolution in NDV strains and relative molecular mechanism. Research on virus-cell interaction and antiviral innate immunity, and vaccine R&D of avian diseases.               Publications He has published over 180 papers on professional magazines. There are more than 70 papers as source of SCI including on J. Virology, J. Immunology, Cancer Letter, Cancer Research, Vaccine, J. General Virology, Molecular Immunology ,D.C.Immunology and so on ,and 4 professional works have published.                Paper list       1.Cao, S., Han, X., Ding, C., Wang, S., Tian, M., Wang, X., Hou, W., Yue, J., Wang, G., Yu, S., 2014. Molecular cloning of the duck mitogen-activated protein kinase 1 (MAPK1) gene and the development of a quantitative real-time PCR assay to detect its expression. Poult Sci. 93, 2158-2167. 2.Chen, H., Wang, W., Song, C., Yu, S., Ding, C., 2010. Marek's disease virus VP22 enhances potentially the immune response of ESAT-6/CFP-10 against Mycobacterium bovis infection. Acta Biochim Biophys Sin (Shanghai). 42, 337-344. 3.Chen, H., Yu, S., Hu, M., Han, X., Chen, D., Qiu, X., Ding, C., 2012. Identification of biofilm formation by Mycoplasma gallisepticum. Vet Microbiol. 161, 96-103. 4.Chen, H., Yu, S., Shen, X., Chen, D., Qiu, X., Song, C., Ding, C., 2011. The Mycoplasma gallisepticum alpha-enolase is cell surface-exposed and mediates adherence by binding to chicken plasminogen. Microb Pathog. 51, 285-290. 5.Chen, H., Zhao, C., Shen, X., Chen, D., Yu, S., Ding, C., 2010. Construction of mini-Tn4001 transposon vector for Mycoplasma gallisepticum. Sci China Life Sci. 53, 1340-1345. 6.Cheng, Y., Huang, Q., Ji, W., Du, B., Fu, Q., An, H., Li, J., Wang, H., Yan, Y., Ding, C., Sun, J., 2015. Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections. Vet Immunol Immunopathol. 163, 183-193. 7.Cheng, Y., Wang, H., Yan, Y., Ding, C., Sun, J., 2015. Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks. Dev Comp Immunol. 52, 144-154. 8.Cheng, Y., Zhang, C., Wang, H., Yan, Y., Ding, C., Sun, J., 2015. Complete genome sequence of duck tembusu virus isolated from pekin ducks in shanghai, china. Genome announcements. 3. 9.Deng, X., Li, X., Shen, Y., Qiu, Y., Shi, Z., Shao, D., Jin, Y., Chen, H., Ding, C., Li, L., Chen, P., Ma, Z., 2010. The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities. Virol J. 7, 348. 10.Han, X., Bai, H., Liu, L., Chen, W., Ding, C., Hu, Q., Qi, K., Yu, S., 2012. [Cloning and expression of luxS and pfs and in vitro biosynthesis autoinducer 2 of avian pathogenic Escherichia coli from Anhui Province]. Wei Sheng Wu Xue Bao. 52, 1167-1172. 11.Han, X., Bai, H., Liu, L., Dong, H., Liu, R., Song, J., Ding, C., Qi, K., Liu, H., Yu, S., 2013. The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli. Microb Pathog. 55, 21-27. 12.Han, X., Ding, C., Chen, H., Hu, Q., Yu, S., 2012. Enzymatic and biological characteristics of enolase in Brucella abortus A19. Mol Biol Rep. 39, 2705-2711. 13.Han, X., Ding, C., He, L., Hu, Q., Yu, S., 2011. Development of loop-mediated isothermal amplification (LAMP) targeting the GroEL gene for rapid detection of Riemerella anatipestifer. Avian Dis. 55, 379-383. 14.Han, X., Hu, Q., Ding, S., Chen, W., Ding, C., He, L., Wang, X., Ding, J., Yu, S., 2012. Identification and immunological characteristics of chaperonin GroEL in Riemerella anatipestifer. Appl Microbiol Biotechnol. 93, 1197-1205. 15.Han, X., Sun, X., Shan, X., Zhang, M., Song, J., Tian, M., Fan, G., Wang, S., Tong, Y., Ding, C., Yu, S., 2014. In vivo-induced argininosuccinate lyase plays a role in the replication of Brucella abortus in RAW264.7 cells. Microbiology. 160, 567-575. 16.Han, X., Tong, Y., Tian, M., Sun, X., Wang, S., Ding, C., Yu, S., 2014. Characterization of the immunogenicity and pathogenicity of malate dehydrogenase in Brucella abortus. World journal of microbiology & biotechnology. 30, 2063-2070. 17.Han, X., Tong, Y., Tian, M., Zhang, Y., Sun, X., Wang, S., Qiu, X., Ding, C., Yu, S., 2014. Enzymatic activity analysis and catalytic essential residues identification of Brucella abortus malate dehydrogenase. ScientificWorldJournal. 2014, 973751. 18.Han, Y., Han, X., Bai, H., Wang, S., Meng, Q., Ding, C., Yu, S., 2013. [RmlA gene deletion affects biofilm formation by avian pathogenic Escherichia coli]. Wei Sheng Wu Xue Bao. 53, 1056-1062. 19.Han, Y., Han, X., Wang, S., Meng, Q., Zhang, Y., Ding, C., Yu, S., 2014. The waaL gene is involved in lipopolysaccharide synthesis and plays a role on the bacterial pathogenesis of avian pathogenic Escherichia coli. Vet Microbiol. 172, 486-491. 20.Hou, W., Wang, S., Wang, X., Han, X., Fan, H., Cao, S., Yue, J., Wang, Q., Jiang, W., Ding, C., Yu, S., 2015. Development of colloidal gold immunochromatographic strips for detection of Riemerella anatipestifer. PLoS One. 10, e0122952. 21.Hu, Q., Ding, C., Tu, J., Wang, X., Han, X., Duan, Y., Yu, S., 2012. Immunoproteomics analysis of whole cell bacterial proteins of Riemerella anatipestifer. Vet Microbiol. 157, 428-438. 22.Hu, Q., Han, X., Zhou, X., Ding, C., Zhu, Y., Yu, S., 2011. OmpA is a virulence factor of Riemerella anatipestifer. Vet Microbiol. 150, 278-283. 23.Hu, Q., Han, X., Zhou, X., Ding, S., Ding, C., Yu, S., 2010. Characterization of biofilm formation by Riemerella anatipestifer. Vet Microbiol. 144, 429-436. 24.Hu, Q., Tu, J., Han, X., Zhu, Y., Ding, C., Yu, S., 2011. Development of multiplex PCR assay for rapid detection of Riemerella anatipestifer, Escherichia coli, and Salmonella enterica simultaneously from ducks. J Microbiol Methods. 87, 64-69. 25.Hu, Q., Zhu, Y., Tu, J., Yin, Y., Wang, X., Han, X., Ding, C., Zhang, B., Yu, S., 2012. Identification of the genes involved in Riemerella anatipestifer biofilm formation by random transposon mutagenesis. PLoS One. 7, e39805. 26.Li, X., Luo, J., Wang, S., Shen, Y., Qiu, Y., Wang, X., Deng, X., Liu, X., Bao, W., Liu, P., Zhou, J., Ding, C., Ma, Z., 2010. Engineering, expression, and immuno-characterization of recombinant protein comprising multi-neutralization sites of rabies virus glycoprotein. Protein Expr Purif. 70, 179-183. 27.Li, X., Qiu, Y., Shen, Y., Ding, C., Liu, P., Zhou, J., Ma, Z., 2008. Splicing together different regions of a gene by modified polymerase chain reaction-based site-directed mutagenesis. Anal Biochem. 373, 398-400. 28.Liu, H., Wang, X., Ding, C., Han, X., Cheng, A., Wang, S., Yu, S., 2013. Development and evaluation of a trivalent Riemerella anatipestifer-inactivated vaccine. Clin Vaccine Immunol. 20, 691-697. 29.Liu, J., Cong, Y., Yin, R., Ding, C., Yu, S., Liu, X., Wang, C., Ding, Z., 2015. The deletion of an extra six nucleotides in the 5' -untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence. BMC Vet Res. 10, 964. 30.Liu, L., Han, X., Liu, R., Bai, H., Dong, H., Ding, C., Liu, H., Yu, S., 2013. [Effect of autoinducer 2 on Riemerell antatipestifer adherence and invasion to Vero cells]. Wei Sheng Wu Xue Bao. 53, 313-319. 31.Meng, C., Qiu, X., Jin, S., Yu, S., Chen, H., Ding, C., 2012. Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus. Arch Virol. 157, 869-880. 32.Meng, C., Zhou, Z., Jiang, K., Yu, S., Jia, L., Wu, Y., Liu, Y., Meng, S., Ding, C., 2012. Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication. Arch Virol. 157, 1011-1018. 33.Qiu, X., Yu, Y., Yu, S., Zhan, Y., Wei, N., Song, C., Sun, Y., Tan, L., Ding, C., 2014. Development of strand-specific real-time RT-PCR to distinguish viral RNAs during Newcastle disease virus infection. ScientificWorldJournal. 2014, 934851. 34.Qiu, Y., Shen, Y., Li, X., Ding, C., Ma, Z., 2008. Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Dev Comp Immunol. 32, 1522-1530. 35.Song, C., Liao, Y., Gao, W., Yu, S., Sun, Y., Qiu, X., Tan, L., Cheng, A., Wang, M., Ma, Z., Ding, C., 2014. Virulent and attenuated strains of duck hepatitis A virus elicit discordant innate immune responses in vivo. J Gen Virol. 95, 2716-2726. 36.Song, C., Wan, H., Yu, S., Han, X., Qiu, X., Hu, Q., Tan, L., Ding, C., 2012. Rapid detection of duck hepatitis virus type-1 by reverse transcription loop-mediated isothermal amplification. J Virol Methods. 182, 76-81. 37.Sun, Y., Ding, N., Ding, S. S., Yu, S., Meng, C., Chen, H., Qiu, X., Zhang, S., Yu, Y., Zhan, Y., Ding, C., 2013. Goose RIG-I functions in innate immunity against Newcastle disease virus infections. Mol Immunol. 53, 321-327. 38.Sun, Y., Yu, S., Ding, N., Meng, C., Meng, S., Zhang, S., Zhan, Y., Qiu, X., Tan, L., Chen, H., Song, C., Ding, C., 2014. Autophagy benefits the replication of Newcastle disease virus in chicken cells and tissues. J Virol. 88, 525-537. 39.Sun, Y. J., Chen, H. J., Song, C. P., Yu, Y., Qiu, X. S., Yu, S. Q., Ding, C., 2010. [Preparation of monoclonal antibodies against HN protein of Class I Newcastle disease virus virulent strain]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 26, 464-466. 40.Tan, L., Chen, H., Yu, S., Qiu, X., Song, C., Chen, D., Zhang, S., Zhang, F., He, S., Shen, X., Hu, M., Ding, C., 2013. A SOE-PCR method of introducing multiple mutations into Mycoplasma gallisepticum neuraminidase. J Microbiol Methods. 94, 117-120. 41.Tan, L., Hu, M., Yu, S., Wang, X., Lu, F., Liu, F., Qiu, X., Song, C., Sun, Y., Ding, C., 2015. Characterization of the chaperonin GroEL in Mycoplasma gallisepticum. Arch Microbiol. 197, 235-244. 42.Tian, M., Qu, J., Han, X., Ding, C., Wang, S., Peng, D., Yu, S., 2014. Mechanism of Asp24 upregulation in Brucella abortus rough mutant with a disrupted O-antigen export system and effect of Asp24 in bacterial intracellular survival. Infect Immun. 82, 2840-2850. 43.Tian, M., Qu, J., Han, X., Zhang, M., Ding, C., Ding, J., Chen, G., Yu, S., 2013. Microarray-based identification of differentially expressed genes in intracellular Brucella abortus within RAW264.7 cells. PLoS One. 8, e67014. 44.Tu, J., Lu, F., Miao, S., Ni, X., Jiang, P., Yu, H., Xing, L., Yu, S., Ding, C., Hu, Q., 2014. The siderophore-interacting protein is involved in iron acquisition and virulence of Riemerella anatipestifer strain CH3. Vet Microbiol. 168, 395-402. 45.Wang, J., Cong, Y., Yin, R., Feng, N., Yang, S., Xia, X., Xiao, Y., Wang, W., Liu, X., Hu, S., Ding, C., Yu, S., Wang, C., Ding, Z., 2015. Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings. Virus Res. 203, 77-83. 46.Wang, S., Dai, J., Meng, Q., Han, X., Han, Y., Zhao, Y., Yang, D., Ding, C., Yu, S., 2014. DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Front Microbiol. 5, 588. 47.Wang, S., Meng, Q., Dai, J., Han, X., Han, Y., Ding, C., Liu, H., Yu, S., 2014. Development of an allele-specific PCR assay for simultaneous sero-typing of avian pathogenic Escherichia coli predominant O1, O2, O18 and O78 strains. PLoS One. 9, e96904. 48.Wang, X., Ding, C., Han, X., Wang, S., Yue, J., Hou, W., Cao, S., Zou, J., Yu, S., 2015. Complete Genome Sequence of Riemerella anatipestifer Serotype 1 Strain CH3. Genome announcements. 3. 49.Wang, X., Ding, C., Wang, S., Han, X., Hou, W., Yue, J., Zou, J., Yu, S., 2014. The AS87_04050 gene is involved in bacterial lipopolysaccharide biosynthesis and pathogenicity of Riemerella anatipestifer. PLoS One. 9, e109962. 50.Wang, X., Ding, C., Wang, S., Han, X., Yu, S., 2015. Whole-genome Sequence Analysis and Genome-wide Virulence Gene Identification of Riemerella anatipestifer Strain Yb2. Appl Environ Microbiol. 51.Yu, Y., Qiu, X., Xu, D., Zhan, Y., Meng, C., Wei, N., Chen, H., Tan, L., Yu, S., Liu, X., Qin, A., Ding, C., 2012. Rescue of virulent class I Newcastle disease virus variant 9a5b-D5C1. Virol J. 9, 120. 52.Zhang, F., Bao, S., Yu, S., Cheng, J., Tan, L., Qiu, X., Song, C., Dai, Y., Fei, R., Ding, C., 2015. Development of a loop-mediated isothermal amplification targeting a gene within the pyruvate dehydrogenase complex, the pdhA gene, for rapid detection of Mycoplasma gallisepticum. J Vet Diagn Invest. 27, 260-267. 53.Zhang, S., Sun, Y., Chen, H., Dai, Y., Zhan, Y., Yu, S., Qiu, X., Tan, L., Song, C., Ding, C., 2014. Activation of the PKR/eIF2alpha signaling cascade inhibits replication of Newcastle disease virus. Virol J. 11, 62. 54.Zheng, W., Li, J., Wang, S., Cao, S., Jiang, J., Chen, C., Ding, C., Qin, C., Ye, X., Gao, G. F., Liu, W., 2015. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza a virus nucleoprotein. J Virol. 89, 5822-5834. 55.Zhu, Y., Li, C., Bi, Z., Chen, Z., Meng, C., Wang, G. J., Ding, C., Liu, G., 2015. Protective immune responses in ducklings induced by a suicidal DNA vaccine of the sigma C gene of novel duck reovirus. Vet Immunol Immunopathol. 165, 88-92. 56.Zhu, Y. Q., Li, C. F., Bi, Z. L., Chen, Z. Y., Meng, C. C., Wang, G. J., Ding, C., Liu, G. Q., 2015. Molecular characterization of a novel reovirus isolated from Pekin ducklings in China. Arch Virol. 160, 365-369. 57.Zou, J., Wang, X., Tian, M., Cao, S., Hou, W., Wang, S., Han, X., Ding, C., Yu, S., 2015. The M949_1556 gene plays a role on the bacterial antigenicity and pathogenicity of Riemerella anatipestifer. Vet Microbiol. 177, 193-200.