Zhiyong Ma   Deputy Director of SHVRI Head of Division of Swine Infectious Diseases  Ph. D,Professor   E-mail: zhiyongma@shvri.ac.cn Tel: 021-34293139 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2003-2006 Postdoctoral, Cell Biology, Department of Cell Biology, University of Cincinnati College of Medicine, OH, USA 1998-2003 PhD, Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan 1988-1991 Master, Animal Infectious Diseases, Nanjing Agricultural University, Nanjing, China. 1983-1988 DVM, Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.   Professional Experience   2013-Present, Deputy Director, Shanghai Veterinary Research Institute, CAAS 2006-Present, Professor, Swine Infectious Diseases, Shanghai Veterinary Research Institute, CAAS 2003-2006 Postdoctoral, Cell Biology, Department of Cell Biology, University of Cincinnati College of Medicine, OH, USA 1991-1998, Lecturer, Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.   Current Research Topics   Mechanisms of host innate immunity against virus infection.  Role of tumor suppressor p53 in regulation of innate immune response. Epidemiology of flaviviruses (Japanese encephalitis virus).   Publications   [1]Yan W, Wei J, Deng X, Shi Z, Zhu Z, Shao D, Li B, Wang S, Tong G, Ma Z. Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection. BMC Med Genomics. 2015 Aug 18;8:52. doi: 10.1186/s12920-015-0127-8. [2]Li B, Zhang Y, Wei J, Shao D, Liu K, Shi Y, Qiu Y, Ma Z. Characterization of a novel small plasmid carrying the florfenicol resistance gene floR in Haemophilus parasuis. J Antimicrob Chemother. 2015 Aug 5. pii: dkv230.  [3]Zhu Z, Yang Y, Wei J, Shao D, Shi Z, Li B, Liu K, Qiu Y, Zheng H, Ma Z. Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53. Biochem Biophys Res Commun. 2014 Oct 22;454(1):189-195. [4]Wang S, Zhang S, Liu Z, Liu P, Shi Z, Wei J, Shao D, Li B, Ma Z. Molecular characterization of enterohemorrhagic E. coli O157 isolated from animal fecal and food samples in Eastern China. Scientific World Journal. 2014;2014:946394.  [5]Shi Z, Wei J, Deng X, Li S, Qiu Y, Shao D, Li B, Zhang K, Xue F, Wang X, Ma Z. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model. Virol J. 2014 Jan 23;11:10. doi: 10.1186/1743-422X-11-10. [6]Zhu Z, Wei J, Shi Z, Yang Y, Shao D, Li B, Wang X, Ma Z. Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53. Biochem Biophys Res Commun. 2013 Jun 28;436(2):204-11. doi: 10.1016/j.bbrc.2013.05.074. Epub 2013 May 29. [7]Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza a virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. [8]Li B, Wendlandt S, Yao J, Liu Y, Zhang Q, Shi Z, Wei J, Shao D, Schwarz S, Wang S, Ma Z. Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin. J Antimicrob Chemother. 2013 Jun;68(6):1251-5. doi: 10.1093/jac/dkt015. [9]Wang X, Deng X, Yan W, Zhu Z, Shen Y, Qiu Y, Shi Z, Shao D, Wei J, Xia X, Ma Z. Stabilization of p53 in influenza a virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53. J Biol Chem. 2012 May 25;287(22):18366-75. [10]Peng LN, Li L, Qiu YF, Miao JH, Gao XQ, Zhou Y, Shi ZX, Xu YL, Shao DH, Wei JC, Ma ZY. Glycyrrhetinic acid extracted from Glycyrrhiza uralensis Fisch. induces the expression of Toll-like receptor 4 in Ana-1 murine macrophages. J Asian Nat Prod Res. 2011 Oct;13(10):942-50. [11]Deng X, Shi Z, Li S, Wang X, Qiu Y, Shao D, Wei J, Tong G, Ma Z. Characterization of nonstructural protein 3 of a neurovirulent Japanese encephalitis virus strain isolated from a pig. Virol J. 2011 May 9;8:209. [12]Li L, Peng L, Miao J, Qiu Y, Zhou Y, Gao X, Xu Y, Shi Z, Shao D, Ma Z. Icariin induces the Expression of Toll-like Receptor 9 in Ana-1 Murine Macrophages. Phytother Res. 2011 Nov;25(11):1732-5.  [13]Shao D, Shi Z, Wei J, Ma Z. A brief review of foodborne zoonoses in China. Epidemiol Infect. 2011 Oct;139(10):1497-504. [14]Deng X, Li X, Shen Y, Qiu Y, Shi Z, Shao D, Jin Y, Chen H, Ding C, Li L, Chen P, Ma Z. The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities. Virology Journal 2010, 7:348 doi:10.1186/1743-422X-7-348.  [15]Wang X, Shen Y, Qiu Y, Shi Z, Shao D, Chen P, Tong G, Ma Z. The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis, Biochem Biophys Res Commun, 2010,395(1):141-5. [16]Li X, Luo J, Wang S, Shen Y, Qiu Y, Wang X, Deng X, Liu X, Bao W, Liu P, Zhou J, Ding C, Ma Z. Engineering, expression, and immuno-characterization of recombinant protein comprising multi-neutralization sites of rabies virus, Protein Expr Purif. 2010, 70(2):179-83. [17]Shen Y, Wang X, Guo L, Qiu Y, Li X, Yu H, Xiang H, Tong G, Ma Z. Influenza A virus induces p53 accumulation in a biphasic pattern. Biochem Biophys Res Commun. 2009,382(2):331-5.  [18]Qiu Y, Shen Y, Li X, Liu Q, Ma Z. Polyclonal antibody to porcine p53 protein: a new tool for studying the p53 pathway in a porcine model. Biochem Biophys Res Commun. 2008 Dec 5;377(1):151-5.  [19]Qiu Y, Shen Y, Li X, Ding C, Ma Z. Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Dev Comp Immunol. 2008;32(12):1522-30. [20]Li X, Qiu Y, Shen Y, Ding C, Liu P, Zhou J, Ma Z. Splicing together different regions of a gene by modified polymerase chain reaction-based site-directed mutagenesis. Anal Biochem. 2008 Feb 15;373(2):398-400. [21]Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K. Interaction between ROCK II and Nucleophosmin/B23 in the Regulation of Centrosome Duplication. Mol Cell Biol. 2006 Dec;26(23):9016-34. [22]Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG, Fukasawa K. Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene. 2006;25(39):5377-90.