GUOFENG CHENG    Head of Innovative Group of Animal Schistosomiasis Ph. D,Professor   E-mail: chenggfeng@shvri.ac.cn Tel: 021-34293659 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2007-2008 Research Associate , Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, USA  2005-2007 Post Doctoral Fellow, Department of Department of Biochemistry and Molecular Genetics, University of Colorado, USA 2000-2005 PhD, Chinese Academy of Agricultural Sciences, Shanghai, China 1994-1998  B.Sc., Hebei Agricultural University, China.     Current Research Topics   Mechanisms of sexual maturation and egg production in Schistosoma japonicum Mechanisms of host-pathogen interaction in Schistosoma japonicum Functions of non-coding RNAs in Schistosoma japonicum Identification of drug target against schistosomiasis   Selected Publications   [1]Zhu L, Dao J, Du X, Li H, Lu K, Liu J, Cheng G*. Altered levels of circulating miRNAs are associated Schistosoma japonicum infection in mice. Parasit Vectors. 2015 Apr 1;8:196. doi: 10.1186/s13071-015-0806-5.(2014 SCI IF=3.43) [2]Zhu L, Liu J, Cheng G*. Role of microRNAs in schistosomes and schistosomiasis. Front Cell Infect Microbiol. 2014 Nov 11;4:165. doi: 10.3389/fcimb.2014.00165.(2014 SCI IF=3.719) [3]Cheng G*. Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy. Adv Drug Deliv Rev. 2015 Jan;81:75-93. (2015 SCI IF=15.038). [4]Hu, Zhu l, Luo R, Dao J, Zhao J, Shi Y, Li H, Lu K, Feng X, Lin J, Liu J, Cheng G*. Evaluation of protective immune response in mice by vaccination the recombinant adenovirus for expressing Schistosoma japonicum inhibitor apoptosis protein. Parasitology Research. 2014, 113(11):4261-9. doi: 10.1007/s00436-014-4104-5. (2014 SCI IF=2.327). [5]Dao J, Zhu L, Luo R, Hu C, Wang Y, Li H, Lu K, Liu J, Lin J, Cheng G*. Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum. Parasitology Research. 2014, 113(11):4065-71. (2014 SCI IF=2.327). [6]He X, Jing Z*, Cheng G*. MicroRNAs: new regulators of Toll-like receptor signalling pathways. Biomed Res Int. 2014: 945169. doi: 10.1155/2014/945169. (2014 SCI IF=2.706). [7]Cheng G*, Lin J. Parasitic helminths: a useful resource for inflammatory and autoimmune therapy. J Bioanal Biomed. 2013, 5: 075-076. doi:10.4172/1948-593X.1000084.  [8]Cheng G*, Luo R, Hu C, Cao J, Jin Y. Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum. Parasitology. 2013 Aug 13:1-11. (2011 SCI IF=2.96). [9]Cheng G*, Luo R, Hu C, Lin J, Bai Z, Zhang B, Wang H. TiO2-based phosphoproteomic analysis of schistosomes: characterization of phosphorylated proteins in the different stages and sex of Schistosoma japonicum. J Proteome Res. 2013 Feb 1;12(2):729-42. (2011 SCI IF=5.11). [10]Luo R, Zhou C, Shi Y, Zhao J, Cheng G*. Molecular characterization of a cytokine-induced apoptosis inhibitor from Schistosoma japonicum. Parasitol Res. 2012 Dec;111(6):2317-24. (2011 SCI IF=2.149). [11]Cheng G* and Jin YX. microRNAs: Potentially Important Regulators for Schistosome Development and Therapeutic Targets against Schistosomiasis. Parasitology. 2012 Apr;139(5):669-79. (2011 SCI IF=2.96). [12]Luo R, Zhou C, Lin J, Yang D, Shi Y, Cheng G*. Identification of in vivo protein phosphorylation sites in human pathogen Schistosoma japonicum by a phosphoproteomic approach. J Proteomics. 2012, 75(3):868-77. (2010 SCI IF=5.047) [13]Chen J, Yang Y, Guo S, Peng J, Liu Z, Li J, Lin J*, Cheng G*. Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum. Parasitol Res. 2010;107(4):889-99. (2010 SCI IF=1.812) [14]Peng J, Yang Y, Feng X, Cheng G*, Lin J*. Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum. Parasitol Res. 2010;106(4):967-76. (2010 SCI IF=1.812) [15]Cheng G, Fu Z, Lin J, Shi Y, Zhou Y, Jin Y, Cai Y. In vitro and in vivo evaluation of small interference RNA-mediated gynaecophoral canal protein silencing in Schistosoma japonicum. J Gene Med. 2009;11(5):412-21. (2009 SCI IF=2.986) [16]Cheng G, Zhu L, Mahato RI. Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. Mol Pharm. 2008;5(6):1093-102. (2008 SCI IF=4.565) [17]Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm Res. 2008;25(1):72-86. (2008 SCI IF=4.024) [18]Cheng G, Davis RE. An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol. 2007;155(2):167-71. (2007 SCI IF=2.896) 【Selected by Faculty 1000 biology】 [19]Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007;153(2):95-106. (2007 SCI IF=2.896) [20]Cheng G, Cohen L, Ndegwa D, Davis RE. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006 13;281(2):733-43. (2006 SCI IF=5.808) [21]Cheng GF, Lin JJ, Shi Y, Jin YX, Fu ZQ, Jin YM, Zhou YC, Cai YM. Dose-dependent inhibition of gynecophoral canal protein gene expression in vitro in the schistosome (Schistosoma japonicum) by RNA interference. Acta Biochim Biophys Sin. 2005;37(6):386-90. (2005 SCI IF=0.505) [22]Cheng GF, Lin JJ, Feng XG, Fu ZQ, Jin YM, Yuan CX, Zhou YC, Cai YM. Proteomic analysis of differentially expressed proteins between the male and female worm of Schistosoma japonicum after pairing. Proteomics. 2005;5(2):511-21. (2005 SCI IF=6.08) [23]Cheng G, Danquah M and Mahato RI (2009) MicroRNAs as therapeutic targets for cancer. In: Lu Y and Mahato RI (eds) Pharmaceutical Perspectives of Cancer Therapeutics (ISBN: 978-1-4419-0130-9) Springer, New York, NY. pp441-474.