JINLIN ZHOU   Ph. D, Head of Division of Animal parasitology  Chief-scientist，Professor   E-mail: jinlinzhou@shvri.ac.cn Tel: 021-34293138 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2000-2002 Postdoctoral, Department of Veterinary Medicine, Hokkaido University, Sapporo, Japan. 1995-1998 PhD, Veterinary Parasitology, Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China.  1989-1992 MS degree, Veterinary Parasitology, Nanjing Agricultural University, Nanjing, China. 1985-1989 BSc degree, Veterinary Medicine, Anhui Agriculture University, Hefei, China   Professional Experience   2007.1-present, Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China 2006.9-2006.12, Associate Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China 2004.4-2006.8, Visit Scientist, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan 2002.10-2004.3, Associate Professor, Shanghai Institute of Animal parasitology, Chinese Academy of Agricultural Sciences. Shanghai, China   Current Research Topics   Development of new control strategies for ticks  Epidemiology of emerging and re-emerging protozoan diseases in China The relationship between ticks and tick borne protozoan   Publications   1.Wang Y, Yu X, Cao J, Zhou Y, Gong H, Zhang H, Li X, Zhou J. Characterization of a secreted cystatin from the tick Rhipicephalus haemaphysaloides, Experimental and Applied Acarology. 2015,67(2):289-298.   2.Zhang H, Yang S, Gong H, Cao J, Zhou Y, Zhou J. Functional analysis of a novel cysteine-rich antimicrobial peptide from the salivary glands of the tick Rhipicephalus haemaphysaloides, Parasitology Research. 2015, 114(10):3855-3863.   3.Wang Y, Zhou Y, Gong H, Cao J, Zhang H, Li X, Zhou J. Functional characterization of a cystatin from the tick Rhipicephalus haemaphysaloides. Parasites & Vectors, 2015, 8:140.   4.Terkawi MA, Cao S, Herbas MS, Nishimura M, Li Y, Moumouni PF, Pyarokhil AH, Kondoh D, Kitamura N, Nishikawa Y, Kato K, Yokoyama N, Zhou J, Suzuki H, Igarashi I, Xuan X. Macrophages are the determinant of resistance to and outcome of nonlethal Babesia microti infection in mice. Infection and Immunity. 2015,83(1):8-16.   5.Xie YT, Lai DH, Liu GY, Zhou J, Lun ZR. Severe fever with thrombocytopenia syndrome in China. Lancet Infection Diseases. 2015 15(2):145    6.Gong H, Qin S, Wan X,Zhang H,Zhou Y, Cao J,Xuan X, Suzuki H, Zhou J. Immunoglobulin G binding protein (IGBP)from Rhipicephalus haemaphysaloides: identification, expression, and binding specificity. Parasitology Research,2014, 113:4387–4395.   7.Li Y, Luo Y, Cao S, Terkawi MA, Lan DTB, Long PT, Yu L, Zhou M, Gong H, Zhang H, Zhou J, Yokoyama N, Suzuki H, Xuan X.  Molecular and seroepidemiological survey of Babesia bovis and Babesia bigemina infections in cattle and water buffaloes in the central region of Vietnam. Tropical Biomedicine, 2014, 31(3): 406–413.   8.Li C, Cao J, Zhou Y, Zhang H, Gong H, Zhou J. The midgut bacterial flora of laboratory-reared hard ticks, Haemaphysalis longicornis, Hyalomma asiaticum, and Rhipicephalus haemaphysaloides. Journal of Integrative Agriculture, 2014, 13(8): 1766-1771.   9.Cao J, Shi L, Zhou Y, Gao X, Zhang H, Gong H,Zhou J. Characterization of a new Kunitz-type serine protease inhibitor from the hard tick Rhipicephalus haemaphysaloides. Archives of Insect Biochemistry and Physiology, 2013, 84:104–113.    10.Lin Z, Cao J, Zhang H, Zhou Y, Deng M, Li G, Zhou J. Comparison of three molecular detection methods for detection of Trichinella in infected pigs. Parasitology Research. 2013, 112:2087–2093.    11.Yu Y, Cao J, Zhou Y, Zhang H,Zhou J. Isolation and characterization of two novel serpins from the tick Rhipicephalus haemaphysaloides, Tick and Tick Borne Diseases,2013,4:297-303.   12.Zhang H, Zhang Y, Cao J, Zhou Y, Wang N, Zhou J. Determination of stage interconversion in vitro and in vivo by construction of transgenic Toxoplasma gondii that stably express stage-specific fluorescent proteins. Experimental Parasitology.2013, 134:275–280.   13.Zhou Y, Zhang H, Cao J, Gong H, Zhou J, Isolation and genotyping of Toxoplasma gondii from domestic rabbits in China to reveal the prevalence of type III strains, Veterinary Parasitology, 2013,193,270– 276.   14.Zhou J, Zhou Y, Cao J, Zhang H, Yu Y, Distinctive microRNAs profiles in the salivary glands of Haemaphysalis longicornis related to tick blood-feeding, Experimental and Applied Acarology,2013, 59:339–349.   15.Lin Z, Zhang Y, Zhang H, Zhou Y, Cao J, Zhou J. Comparison of loop-mediated isothermal amplification (LAMP) and real-time PCR method targeting a 529-bp repeat element for diagnosis of toxoplasmosis. Veterinary Parasitology, 2012,185,296- 300.    16.Xiang F, Zhou Y, Zhou J , Identification of Differentially Expressed Genes in the Salivary Gand of Rhipicephalus haemaphysaloides by the Suppression Subtractive Hybridization Approach. Journal of Integrative Agriculture, 2012, 11,101-108.    17.Zhang H, Zhang W, Wang X, Zhou Y, Wang N, Zhou J. Identification of a cysteine-rich antimicrobial peptide from salivary glands of the tick Rhipicephalus haemaphysaloides. Peptides. 2011, 32: 441–446   18.Gao X, Shi L, Zhou Y, Cao J, Zhang H, Zhou J. Characterization of the anticoagulant protein Rhipilin-1 from the Rhipicephalus haemaphysaloides tick. Journal of Insect Physiology. 2011, 57:339–343.   19.Zhou J, Liao M, Gong H, Xuan X, Fujisaki K. Characterization of Hlcyst-3 as a member of cystatins from the tick Haemaphysalis longicornis. Experimental and Applied Acarology. 2010, 51(4):327-333.   20.Zhang H, Nishikawa Y, Yamagishi J, Zhou J, Ikehara Y, Kojima N, Yokoyama N, Xuan X. Neospora caninum: Application of apical membrane antigen 1 encapsulated in the oligomannose-coated liposomes for reduction of offspring mortality from infection in BALB/c mice. Experimental Parasitology. 2010;125(2):130-136.   21.Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K. Characterization of an intracellular cystatin homolog from the tick Haemaphysalis longicornis.  Veterinary Parasitology. 2009，160:180-183.    22.Xiang F, Zhang J, Zhou Y, Li Z, Gong H, Zhou J. Protemic analysis of proteins in   the salivary glands of the fed and unfed female tick Rhipicephalus haemaphysaloides. Agricultural Sciences in China. 2009, 8(1):121-127   23.Liao M, Zhou J, Gong H, Boldbaatar D, Shirafuji R, Battur B, Nishikawa Y, Fujisaki K. Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis. Journal of Insect Physiology. 2009,55:164-173.    24.Gong H, Umemiya R, Zhou J, Liao M, Zhang H, Jia H, Nishikawa Y, Xuan X, Fujisaki K.Blocking the secretion of saliva by silencing the HlYkt6 gene in the tick Haemaphysalis longicornis. Insect Biochemistry and Molecular Biology. 2009,39:372-381.   25.Jia H, Terkawi MA, Aboge GO, Goo YK, Ma L, Zhou J, Nishikawa Y, Igarashi I, Fujisaki K, Xuan X. Identification of secreted antigen 3 from Babesia gibsoni. Clinicl Vaccine Immunology. 2009,16:944-948.   26.Liao M, Boldbaatar D, Gong H, Huang P, Umemiya R, Harnnoi T, Zhou J, Tanaka T, Suzuki H, Xuan X, Fujisaki K.  Functional analysis of protein disulfide isomerases in blood feeding, viability and oocyte development in Haemaphysalis longicornis ticks. Insect Biochemistry and Molecular Biology. 2008,38:285-295.   27.Gong H, Liao M, Zhou J, Hatta T, Huang P, Zhang G, Kanuka H, Nishikawa Y, Xuan X, Fujisaki K.  Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis. Veterinary Parasitology. 2008,151:268-278.   28.Goo YK, Jia H, Aboge GO, Terkawi MA, Kuriki K, Nakamura C, Kumagai A, Zhou J, Lee EG, Nishikawa Y, Igarashi I, Fujisaki K, Xuan X.  Babesia gibsoni: Serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP. Experimental Parasitology. 2008,118:555-560.   29.Jia H, Terkawi MA, Aboge GO, Goo YK, Zhou J, Lee EG, Nishikawa Y, Igarashi I, Fujisaki K, Xuan X.  Babesia gibsoni: identification of an immunodominant, interspersed repeat antigen. Experimental Parasitology. 2008,118:146-149.   30.Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K. Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. Peptides. 2007，28:1304-1310.   31.Zhou J, Jia H, Nishikawa Y, Fujisaki K, Xuan X. Babesia gibsoni rhoptry-associated protein 1 and its potential use as a diagnostic antigen. Veterinary Parasitology. 2007, 145:16-20.    32.Gong H, Zhou J, Liao M, Hatta T, Harnnoi T, Umemiya R, Inoue N, Xuan X, Fujisaki K. Characterization of a carboxypeptidase inhibitor from the tick Haemaphysalis longicornis. Journal of Insect Physiology. 2007,53:1079-1087.   33.Liao M, Zhou J, Hatta T, Umemiya R, Miyoshi T, Tsuji N, Xuan X, Fujisaki K. Molecular characterization of Rhipicephalus (Boophilus) microplus Bm86 homologue from Haemaphysalis longicornis ticks. Veterinary Parasitology. 2007, 146:148-157.   34.Terkawi MA, Jia H, Zhou J, Lee EG, Igarashi I, Fujisaki K, Nishikawa Y, Xuan X. Babesia gibsoni ribosomal phosphoprotein P0 induces cross-protective immunity against B. microti infection in mice.Vaccine. 2007, 25:2027-2035.   35.Tanaka M, Liao M, Zhou J, Nishikawa Y, Xuan X, Fujisaki K. Molecular cloning of two caspase-like genes from the hard tick Haemaphysalis longicornis. Journal of Veterinary Medicine Sciences. 2007, 69:85-90.    36.Hatta T, Umemiya R, Liao M, Gong H, Harnnoi T, Tanaka M, Miyoshi T, Boldbaatar D, Battsetseg B, Zhou J, Xuan X, Tsuji N, Taylor D, Fujisaki K. RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis. Parasitology Research. 2007, 100: 847-854.   37.Umemiya R, Hatta T, Liao M, Tanaka M, Zhou J, Inoue N, Fujisaki K. Haemaphysalis longicornis: molecular characterization of a homologue of the macrophage migration inhibitory factor from the partially fed ticks. Experimental Parasitology. 2007,115:135-142.    38.Battsetseg B, Matsuo T, Xuan X, Boldbaatar D, Chee SH, Umemiya R, Sakaguchi T, Hatta T, Zhou J, Verdida AR, Taylor D, Fujisaki K. Babesia parasites develop and are transmitted by the non-vector soft tick Ornithodoros moubata (Acari: Argasidae).Parasitology. 2007,134:1-8.    39.Liao M, Hatta T, Umemiya R, Huang P, Jia H, Gong H, Zhou J, Nishikawa Y, Xuan X, Fujisaki K. Identification of three protein disulfide isomerase members from Haemaphysalis longicornis tick. Insect Biochemistry and Molecular Biology. 2007,37:641-654.   40.Zhang G, Huong VT, Battur B, Zhou J, Zhang H, Liao M, Kawase O, Lee EG, Dautu G, Igarashi M, Nishikawa Y, Xuan X.  A heterologous prime-boost vaccination regime using DNA and a vaccinia virus, both expressing GRA4, induced protective immunity against Toxoplasma gondii infection in mice. Parasitology. 2007,134:1339-1346.   41.Aboge GO, Jia H, Kuriki K, Zhou J, Nishikawa Y, Igarashi I, Fujisaki K, Suzuki H, Xuan X. Molecular characterization of a novel 32-kDa merozoite antigen of Babesia gibsoni with a better diagnostic performance by enzyme-linked immunosorbent assay. Parasitology. 2007,134:1185-1194.        42.Zhou J., Liao M, Hatta T, Tanaka M, Xuan X, Fujisaki K  Identification of a follistatin-related protein from the tick Haemaphysalis longicornis and its effect on tick oviposition. Gene 2006，372:191-198.   43.Zhou J., Ueda M., Umemiya R., Battsetseg B., Boldbaatar D., Xuan X., Fujisaki K.. A secreted cystatin from the tick Haemaphysalis longicornis and its distinct expression patterns in relation to innate immunity. Insect Biochemistry and Molecular Biology, 2006，36，527-535.   44.Zhou J., Fukumoto S., Jia H., Yokoyama N., Zhang G.,Fujisaki K., Lin J., Xuan X. Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein. Molecular and Biochemical Parasitology 2006, 148,190-198.   45.Zhou J, Zhang G, Nishikawa Y, Fujisaki K, Xuan X. A 38-kDa protein from Babesia gibsoni and its antibody response in an experimentally infected dog. Veterinary Parasitology 2006, 141:345-348.   46.Zhou J, Yang J, Zhang G, Nishikawa Y, Fujisaki K, Xuan X. Babesia gibsoni: An apical membrane antigen-1 homologue and its antibody response in the infected dogs. Experimental Parasitology 2006, 114:329-333.   47.Zhou J， Gong H， Zhou Y, Xuan X, Fujisaki K. Identification of a glycine-rich protein from the tick Rhipicephalus haemaphysaloides and evaluation of its vaccine potential against tick feeding. Parasitology Research, 2006, 100:77-84.   48.Jia H, Zhou J, Ikadai H, Matsuu A, Suzuki H, Igarashi I, Fujisaki K, Xuan X. Identification of a novel gene encoding a secreted antigen 1 of Babesia gibsoni and evaluation of its use in serodiagnosis. The American Journal of Tropical Medicine and Hygiene. 2006, 75:843-850. 49.Assenga SP, You M, Shy C,. Sakaguchi T, Zhou J. Kibe M, Xuan X, Fujisaki K, The use of a recombinant baculovirus expressing a chitinase from the hard tick Haemaphysalis longicornis and its potential application as a bioacaricide for tick control. Parasitology Researh 2006，98:111-118.   50.Zhou J, Huang B, Suzuki H, Fujisaki K, Igarashi I, Xuan X， Isolation and identification of an actin from Babesia gibsoni. Journal of Parasitology 2006， 92:208-210.   51.Verdida RA.,Xuan X, Fukumoto S, Huang X, Zhou J, Igarashi I, Claveria FG, Nagasawa H. Development of a practical immunochromatographic test with recombinant P50 for the diagnosis of Babesia gibsoni infection in dogs. Parasitology, 2005,131,769-774.   52.Zhou J., Shen J., Liao D., Zhou Y., Lin J. Resistance to drug by different isolates Trypanosoma evansi in China, Acta Tropica, 2004，90:271-275.   53.Zhou J., Ohashi K., Onuma M., cDNA cloning of a Rab5 homologue in Babesia gibsoni,  Journal of Veterinary Medicine Sciences, 2003，65：519-521.   54.Zhou J.,  Mulenga A..,  Yamasaki M..,  Ohashi K..,  Maede Y.,  Onuma M., Babesia gibsoni: Molecular Cloning and Characterization of Rab6 and Rab11 Homologues, Experimental Parasitology, 2002，101:210-214.   55.Zhou J., Shen J., He G., Studies on the comprehensive control of Babesiasis in cattle and Baffaloes, Tropical Animal Health and Production, 1997，29 (4 suppl ): 66-71.