Qinfeng Huang   Ph. D,  Professor   E-mail: qhuang@shvri.ac.cn Tel: 021-34293135 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2011-2014 Postdoctoral, Arenavirus Research, College of Veterinary Medicine, University of Minnesota, MN, USA  2009-2011 Postdoctoral, Parvovirus Research, Department of Microbiology, Molecular Genetics & Immunology, Kansas University Medical Center, KS, USA 2002-2009 PhD, Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China 1994-1998 B.S. of Animal Husbandry, Huazhong Agricultural University, Wuhan, China.   Professional Experience   2014-Present, Professor, Shanghai Veterinary Research Institute, CAAS 2011-2014 Postdoctoral, Arenavirus Research, College of Veterinary Medicine, University of Minnesota, MN, USA  2009-2011 Postdoctoral, Parvovirus Research, Department of Microbiology, Molecular Genetics & Immunology, Kansas University Medical Center, KS, USA   Current Research Topics PRRSV interactions with host signaling pathways Mechanisms of PRRSV-induced immune suppression Virulence determinants and mechanisms of PRRSV Antivirals and vaccines   Publications [1]Qinfeng Huang*, Xuefeng Deng*, Ziying Yan*, Fang Cheng, Yong Luo, Weiran Shen, Diana C. M. Lei-Butters, Aaron Yun Chen, Yi Li, Liang Tang, Maria Söderlund-Venermo, John F. Engelhardt, Jianming Qiu. Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. PLoS Pathogens, 2012 Aug;8(8):e1002899. Epub 2012 Aug 30 (*Co-first author) [2]Qinfeng Huang, Junjie Shao, Shuiyun Lan, Yanqin Zhou, Junji Xing, Changjiang Dong, Yuying Liang, Hinh Ly. In Vitro and in Vivo Characterizations of the Pichinde Viral NP Exoribonuclease Function. Journal of Virology, 2015 Apr 15 pii: JVI.00009-15. [3]Xue Jiang*, Qinfeng Huang*, Wenjian Wang, Haohao Dong, Hinh Ly, Yuying Liang and Changjiang Dong. Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression.  Journal of Biological Chemistry , 2013 Jun 7;288(23):16949-59. doi: 10.1074/jbc.M112.420521. Epub 2013 Apr 24. (*Co-first author) [4]Qinfeng Huang, Yong Luo, Fang Cheng, Sonja Best, Marshall Bloom, Jianming Qiu. Molecular Characterization of the Small Nonstructural Proteins of Parvovirus Aleutian Mink Disease Virus (AMDV) During Infection. Virology, Volumes 452–453, March 2014, Pages 23-31 [5]Gregor D Wallat*, Qinfeng Huang*, Wenjian Wang, Haohao Dong, Hinh Ly, Yuying Liang, Changjiang Dong. High-resolution Structure of the N-terminal Endonuclease Domain of the Lassa Virus L polymerase in Complex with Magnesium Ions. PLoS One. 2014 Feb 7; 9(2): e87577. (*Co-first author) [6]Qinfeng Huang, Xuefeng Deng, Sonja M. Best, Marshall E. Bloom, Jianming Qiu. Internal polyadenylation of parvoviral precursor mRNA limits progeny virus production. Virology, 2012 May 10;426(2):167-177. Epub 2012 Feb 21 [7]Qinfeng Huang, Qingxia Yao, Huiying Fan, Shaobo Xiao, Huanchun Chen. Development of a Vaccine Vector Based on a Subgenomic Replicon of Porcine Reproductive and Respiratory Syndrome Virus. Journal of Virological Methods, Volume 160, Issues 1-2, September 2009, Pages 22-28 [8]Sai Lou, Yong Luo, Fang Cheng, Qinfeng Huang, Weiran Shen, Steve Kleiboeker, John F. Tisdale, Zhengwen Liu and Jianming Qiu. Human parvovirus b19 DNA replication induces a DNA damage response that is dispensable for cell cycle arrest at phase g2/m. Journal of Virology, 2012 Oct;86(19):10748-10758. Epub 2012 Jul 25 [9]Sai Lou, Baoyan Xu, Qinfeng Huang, Ning Zhi, Fang Cheng, Susan Wong, Kevin Brown, Eric Delwart, Zhengwen Liu, Jianming Qiu. Molecular characterization of the newly identified human parvovirus 4 in the family Parvoviridae. Virology, 2012 Jan 5;422(1):59-69. Epub 2011 Oct 30 [10]Wuxiang Guan, Qinfeng Huang, Fang Cheng, Jianming Qiu. Internal Polyadenylation of the Parvovirus B19 Precursor mRNA is Regulated by Alternative Splicing. Journal of Biological Chemistry, 2011 Jul 15;286(28):24793-24805. Epub 2011 May 27 [11]Wuxiang Guan, Fang Cheng, Qinfeng Huang, Steve Kleiboeker, Jianming Qiu. Inclusion of the Central Exon of Parvovirus B19 Precursor mRNA is Determined by Multiple Splicing Enhancers both in the Exon and the Downstream Intron. Journal of Virology, 2011 Mar; 85(5):2463-8.  [12]Youhui Si, Fangyan Yuan, Xijian Liu, Hongru Li, Haitao Chang, Kai Cai, Zhuofei Xu, Qinfeng Huang, Weicheng Bei, Huanchun Chen. Contribution of Glutamine Synthetase to The Virulence of Streptococcus Suis Serotype 2. Veterinary Microbiology, 2009 Oct 20; 139(1-2):80-8. [13]Qingxia Yao, Ping Qian, Qinfeng Huang, Yi Cao, and Huanchun Chen. Comparison of Immune Responses to Different Foot-and-Mouth Disease (FMD) Genetically Engineered Vaccines in Guinea Pigs. Journal of virological methods, 2008, 147 (1), 143-150. [14]Qingxia Yao, Qinfeng Huang, Yi Cao, Ping Qian, and Huanchun Chen. Porcine interferon-gamma protects swine from foot-and-mouth disease virus (FMDV). Veterinary Immunology Immunopathology, 2007, Oct, 2