ZHIQIANG FU   MPVM  Professor   E-mail: fuzhiqiang@shvri.ac.cn Tel: 021-34293618 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2004-2007  MPVM , Graduate School, Chinese Academy of Agricultural Sciences, China  1988-1992  BS, Veterinary Science college, Yangzhou University, Jiangsu, China    Professional Experience   2011-Present, Professor, Animal Schistosomiasis Deptartment, Shanghai Veterinary Research Institute, CAAS 2004-2010, Associate Professor, Animal Schistosomasis Research Group, Shanghai Veterinary Research Institute, CAAS 1999-2003, Research Fellow, Animal Schistosomasis Research Group, Shanghai Veterinary Research Institute, CAAS 1992-1998, Research Assistant, Animal Schistosomasis Research Group, Shanghai Veterinary Research Institute, CAAS   Current Research Topics   The development of diagnosis techniques and vaccines against animal schistosomiasis To understand the Interaction between schistosoma japonicum and its hosts     Publications [1]Zhang, M., Z. Fu, C. Li, Y. Han, X. Cao, H. Han, Y. Liu, et al. "Screening Diagnostic Candidates for Schistosomiasis from Tegument Proteins of Adult Schistosoma Japonicum Using an Immunoproteomic Approach." PLoS Negl Trop Dis 9, no. 2 (Jan 2015): e0003454. [2]Yang, J., Z. Fu, Y. Hong, H. Wu, Y. Jin, C. Zhu, H. Li, et al. "The Differential Expression of Immune Genes between Water Buffalo and Yellow Cattle Determines Species-Specific Susceptibility to Schistosoma Japonicum Infection." PLoS One 10, no. 6 (2015): e0130344. [3]Ta, N., X. Feng, L. Deng, Z. Fu, Y. Hong, J. Liu, H. Li, et al. "Characterization and Expression Analysis of Wnt5 in Schistosoma Japonicum at Different Developmental Stages." Parasitol Res  (Jun 17 2015). [4]Ma, Q. Q., Y. Hong, H. X. Han, K. Lu, S. Ma, T. Wang, Y. T. Liu, et al. "[Preliminary Study on Pro-Apoptotic Gene Bad of Schistosoma Japonicum]." Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 27, no. 2 (Apr 2015): 139-45. [5]Hong, Y., M. Zhang, J. Yang, X. Cao, Q. Han, Y. Han, C. Qiu, et al. "Immunoproteomic Analysis of Schistosoma Japonicum Schistosomulum Proteins Recognized by Immunoglobulin G in the Sera of Susceptible and Non-Susceptible Hosts." J Proteomics 124 (Jun 21 2015): 25-38. [6]Hong, Y., L. Huang, J. Yang, X. Cao, Q. Han, M. Zhang, Y. Han, et al. "Cloning, Expression and Enzymatic Characterization of 3-Phosphoglycerate Kinase from Schistosoma Japonicum." Exp Parasitol 159 (Aug 20 2015): 37-45. [7]Han, H., J. Peng, Y. Hong, Z. Fu, K. Lu, H. Li, C. Zhu, Q. Zhao, and J. Lin. "Comparative Characterization of Micrornas in Schistosoma Japonicum Schistosomula from Wistar Rats and Balb/C Mice." Parasitol Res  (Apr 19 2015). [8]Li, C., M. Zhang, Y. Hong, Y. Han, X. Cao, H. Han, Z. Fu, et al. "[Cloning, Expression and Protective Efficacy Evaluation of Radiation Sensitive Protein 23 (Rad23) from Schistosoma Japonicum]." Sheng Wu Gong Cheng Xue Bao 30, no. 11 (Nov 2014): 1669-78. [9]Han, Y., Z. Fu, Y. Hong, M. Zhang, H. Han, K. Lu, J. Yang, L. I. Xiangrui, and J. Lin. "Inhibitory Effects and Analysis of Rna Interference on Thioredoxin Glutathione Reductase Expression in Schistosoma Japonicum." J Parasitol  (Mar 15 2014). [10]Cao, X., Y. Hong, M. Zhang, Y. Han, M. Wu, X. Wang, X. Guo, et al. "Cloning, Expression and Characterization of Protein Disulfide Isomerase of Schistosoma Japonicum." Exp Parasitol  (Oct 6 2014). [11]Zhang, M., Y. Hong, Y. Han, H. Han, J. Peng, C. Qiu, J. Yang, et al. "Proteomic Analysis of Tegument-Exposed Proteins of Female and Male Schistosoma Japonicum Worms." J Proteome Res 12, no. 11 (Nov 1 2013): 5260-70. [12]Yang, J., Y. Hong, C. Yuan, Z. Fu, Y. Shi, M. Zhang, L. Shen, et al. "Microarray Analysis of Gene Expression Profiles of Schistosoma Japonicum Derived from Less-Susceptible Host Water Buffalo and Susceptible Host Goat." PLoS One 8, no. 8 (2013): e70367. [13]Xiong, Y., D. Ai, P. Meng, M. Wei, Y. Hong, M. Zhang, L. Huang, et al. "Cloning, Expression, and Preliminary Characterization of the Dysferlin Tegument Protein in Schistosoma Japonicum." Parasitol Int  (Jul 25 2013). [14]Qiu, C., Z. Fu, Y. Shi, Y. Hong, S. Liu, and J. Lin. "A Retinoid X Receptor (Rxr1) Homolog from Schistosoma Japonicum: Its Ligand-Binding Domain May Bind to 9-Cis-Retinoic Acid." Mol Biochem Parasitol 188, no. 1 (Mar 2013): 40-50. [15]Hong, Y., A. Sun, M. Zhang, F. Gao, Y. Han, Z. Fu, Y. Shi, and J. Lin. "Proteomics Analysis of Differentially Expressed Proteins in Schistosomula and Adult Worms of Schistosoma Japonicum." Acta Trop 126, no. 1 (Apr 2013): 1-10. [16]Hong, Y., Y. Han, Z. Fu, H. Han, C. Qiu, M. Zhang, J. Yang, et al. "Characterization and Expression of the Schistosoma Japonicum Thioredoxin Peroxidase-2 Gene." J Parasitol 99, no. 1 (Feb 2013): 68-76. [17]Han, H., J. Peng, Y. Hong, M. Zhang, Y. Han, D. Liu, Z. Fu, et al. "Microrna Expression Profile in Different Tissues of Balb/C Mice in the Early Phase of Schistosoma Japonicum Infection." Mol Biochem Parasitol 188, no. 1 (Mar 2013): 1-9. [18]Han, H., J. Peng, Y. Hong, M. Zhang, Y. Han, Z. Fu, Y. Shi, et al. "Comparison of the Differential Expression Mirnas in Wistar Rats before and 10 Days after S.Japonicum Infection." Parasit Vectors 6 (2013): 120. [19]Han, H., J. Peng, Y. Han, M. Zhang, Y. Hong, Z. Fu, J. Yang, J. Tao, and J. Lin. "Differential Expression of Micrornas in the Non-Permissive Schistosome Host Microtus Fortis under Schistosome Infection." PLoS One 8, no. 12 (2013): e85080. [20]Han, H., J. Peng, G. N. Gobert, Y. Hong, M. Zhang, Y. Han, Z. Fu, et al. "Apoptosis Phenomenon in the Schistosomulum and Adult Worm Life Cycle Stages of Schistosoma Japonicum." Parasitol Int 62, no. 2 (Apr 2013): 100-8. [21]Cao, Y., B. Zhao, Y. Han, J. Zhang, X. Li, C. Qiu, X. Wu, et al. "Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma Japonicum." Biomed Res Int 2013 (2013): 952416. [22]Zhu, Z., Z. Fu, M. Zhang, Y. Han, Y. Hong, D. Li, Z. Zhao, et al. "Protective Efficacy Evaluation Induced by Recombinant Protein Lhd-Sj23-Gst of Schistosoma Japonicum Emulsified with Three Different Adjuvants." [In eng]. Parasite Immunol 34, no. 6 (Jun 2012): 341-4. [23]Zhang, M., Y. Han, Z. Zhu, D. Li, Y. Hong, X. Wu, Z. Fu, and J. Lin. "Cloning, Expression, and Characterization of Schistosoma Japonicum Tegument Protein Phosphodiesterase-5." Parasitol Res 110, no. 2 (Feb 2012): 775-86. [24]Yang, J. M., Y. J. Shi, X. G. Feng, Z. Q. Fu, C. X. Yuan, J. M. Liu, Y. Hong, et al. "[Screening and Verification on Characteristic Differentially Expressed Genes of Schistosoma Japonicum from Three Reservoir Hosts]." Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 24, no. 3 (Jun 2012): 279-83. [25]Yang, J., Z. Fu, X. Feng, Y. Shi, C. Yuan, J. Liu, Y. Hong, et al. "Comparison of Worm Development and Host Immune Responses in Natural Hosts of Schistosoma Japonicum, Yellow Cattle and Water Buffalo." BMC Vet Res 8 (2012): 25. [26]Yang, J., X. Feng, Z. Fu, C. Yuan, Y. Hong, Y. Shi, M. Zhang, et al. "Ultrastructural Observation and Gene Expression Profiling of Schistosoma Japonicum Derived from Two Natural Reservoir Hosts, Water Buffalo and Yellow Cattle." PLoS One 7, no. 10 (2012): e47660. [27]Wu, X., B. Zhao, Y. Hong, X. Li, J. Peng, J. Zhang, F. Wang, et al. "Characterization of Schistosoma Japonicum Estrogen-Related Receptor Beta Like 1 and Immunogenicity Analysis of the Recombinant Protein." Exp Parasitol 131, no. 3 (Jul 2012): 383-92. [28]Qiu, C. H., S. F. Liu, Y. Hong, Z. Q. Fu, M. Zhang, M. M. Wei, D. Z. Ai, and J. J. Lin. "[Identification and Preliminary Analysis of a Novel Full-Length Cdna Encoding Retinoid X Receptor 2 from Schistosoma Japonicum]." Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 24, no. 4 (Aug 2012): 440-4. [29]Qiu, C., S. Liu, Y. Hong, Z. Fu, M. Wei, D. Ai, and J. Lin. "Molecular Characterization of Thyroid Hormone Receptor Beta from Schistosoma Japonicum and Assessment of Its Potential as a Vaccine Candidate Antigen against Schistosomiasis in Balb/C Mice." Parasit Vectors 5 (2012): 172. [30]Qiu, C., Y. Hong, Y. Cao, F. Wang, Z. Fu, Y. Shi, M. Wei, S. Liu, and J. Lin. "Molecular Cloning and Characterization of Glutamine Synthetase, a Tegumental Protein from Schistosoma Japonicum." Parasitol Res 111, no. 6 (Dec 2012): 2367-76. [31]Han, Y., M. Zhang, Y. Hong, Z. Zhu, D. Li, X. Li, Z. Fu, and J. Lin. "Characterization of Thioredoxin Glutathione Reductase in Schiotosoma Japonicum." Parasitol Int 61, no. 3 (Sep 2012): 475-80. [32]Han, H., J. Peng, Y. Hong, Z. Fu, J. Xu, J. Lin, and J. Tao. "Molecular Cloning and Characterization of a Cyclophilin a Homologue from Schistosoma Japonicum." Parasitol Res 111, no. 2 (Aug 2012): 807-17. [33]Peng, J., H. Han, G. N. Gobert, Y. Hong, W. Jiang, X. Wang, Z. Fu, et al. "Differential Gene Expression in Schistosoma Japonicum Schistosomula from Wistar Rats and Balb/C Mice." Parasit Vectors 4 (2011): 155. [34]Peng, J., G. N. Gobert, Y. Hong, W. Jiang, H. Han, D. P. McManus, X. Wang, et al. "Apoptosis Governs the Elimination of Schistosoma Japonicum from the Non-Permissive Host Microtus Fortis." PLoS One 6, no. 6 (2011): e21109. [35]Hong, Y., J. Peng, W. Jiang, Z. Fu, J. Liu, Y. Shi, X. Li, and J. Lin. "Proteomic Analysis of Schistosoma Japonicum Schistosomulum Proteins That Are Differentially Expressed among Hosts Differing in Their Susceptibility to the Infection." Mol Cell Proteomics 10, no. 8 (Aug 2011): M110 006098. [36]Yang, J., C. Qiu, Y. Xia, L. Yao, Z. Fu, C. Yuan, X. Feng, and J. Lin. "Molecular Cloning and Functional Characterization of Schistosoma Japonicum Enolase Which Is Highly Expressed at the Schistosomulum Stage." Parasitol Res 107, no. 3 (Aug 2010): 667-77. [37]Wei, F., Y. Zhai, H. Jin, L. Shang, J. Men, J. Lin, Z. Fu, et al. "Development and Immunogenicity of a Recombinant Pseudorabies Virus Expressing Sj26gst and Sjfabp from Schistosoma Japonicum." Vaccine 28, no. 32 (Jul 19 2010): 5161-6. [38]Peng, J., H. Han, Y. Hong, Y. Wang, F. Guo, Y. Shi, Z. Fu, et al. "[Cloning and Expressing of Cyclophilin B Gene from Schistosoma Japonnicum and the Analysis of Immunoprotective Effect]." Sheng Wu Gong Cheng Xue Bao 26, no. 3 (Mar 2010): 317-23. [39]Peng, J., H. Han, Y. Hong, Z. Fu, J. Liu, and J. Lin. "Molecular Cloning and Characterization of a Gene Encoding Methionine Aminopeptidase 2 of Schistosoma Japonicum." Parasitol Res 107, no. 4 (Sep 2010): 939-46. [40]Jin, Y. M., K. Lu, W. F. Zhou, Z. Q. Fu, J. M. Liu, Y. J. Shi, H. Li, and J. J. Lin. "Comparison of Recombinant Proteins from Schistosoma Japonicum for Schistosomiasis Diagnosis." Clin Vaccine Immunol 17, no. 3 (Mar 2010): 476-80. [41]Jiang, W., Y. Hong, J. Peng, Z. Fu, X. Feng, J. Liu, Y. Shi, and J. Lin. "Study on Differences in the Pathology, T Cell Subsets and Gene Expression in Susceptible and Non-Susceptible Hosts Infected with Schistosoma Japonicum." PLoS One 5, no. 10 (2010): e13494. [42]Hong, Y., H. Han, J. Peng, Y. Li, Y. Shi, Z. Fu, J. Liu, J. Lin, and X. Li. "Schistosoma Japonicum: Cloning, Expression and Characterization of a Gene Encoding the Alpha5-Subunit of the Proteasome." Exp Parasitol 126, no. 4 (Dec 2010): 517-25. [43]Hong, Y., H. Han, J. Peng, Y. Li, Y. Shi, Z. Fu, J. Liu, X. Li, and J. Lin. "[Cloning, Expression and Characterization of a Gene Encoding Alpha2 Subunit of the Proteasome in Schistosoma Japonicum]." Sheng Wu Gong Cheng Xue Bao 26, no. 4 (Apr 2010): 509-16. [44]Guo, F. J., Y. Wang, Y. Li, J. B. Peng, Y. Hong, C. H. Qiu, S. Chen, et al. "[Evaluation on the Immuno-Protective Efficacy of the Recombinant Antigen Sjpgam-Sjenol against Schistosoma Japonicum in Mice]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 28, no. 4 (Aug 2010): 246-51. [45]Wei, F., Q. Liu, Y. Zhai, Z. Fu, W. Liu, L. Shang, J. Men, et al. "Il-18 Enhances Protective Effect in Mice Immunized with a Schistosoma Japonicum Fabp DNA Vaccine." Acta Trop 111, no. 3 (Sep 2009): 284-8. [46]Wang, X., G. N. Gobert, X. Feng, Z. Fu, Y. Jin, J. Peng, and J. Lin. "Analysis of Early Hepatic Stage Schistosomula Gene Expression by Subtractive Expressed Sequence Tags Library." Mol Biochem Parasitol 166, no. 1 (Jul 2009): 62-9. [47]Cheng, G., Z. Fu, J. Lin, Y. Shi, Y. Zhou, Y. Jin, and Y. Cai. "In Vitro and in Vivo Evaluation of Small Interference Rna-Mediated Gynaecophoral Canal Protein Silencing in Schistosoma Japonicum." J Gene Med 11, no. 5 (May 2009): 412-21. [48]Chen, H., Z. Q. Fu, L. Chen, C. H. Qiu, G. W. Fu, Y. Li, D. H. Shao, X. G. Feng, and J. J. Lin. "[Immune Protection of Tegument Protein Rsj29 against Schistosoma Japonicum in Mice]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 27, no. 6 (Dec 2009): 476-82. [49]Zhou, Y., J. Lin, L. Yao, X. Wang, Y. Shi, K. Lu, J. Liu, Z. Fu, and L. Tao. "[Cloning, Expressing and Characterizing of a Phosphoglycerate Mutase Gene of Schistosoma Japonncum]." Sheng Wu Gong Cheng Xue Bao 24, no. 9 (Sep 2008): 1550-5. [50]Wei, F., Q. Liu, S. Gao, L. Shang, Y. Zhai, J. Men, L. Jiang, et al. "Enhancement by Il-18 of the Protective Effect of a Schistosoma Japonicum 26kda Gst Plasmid DNA Vaccine in Mice." Vaccine 26, no. 33 (Aug 5 2008): 4145-9. [51]Jia, R., Y. Sun, J. Liu, Z. Fu, C. Yuan, Y. Shi, K. Lu, et al. "[Screening of T7 Phage-Display Cdna Library from Liver of Microtus Fortis with Extracts of Schistosomulum and Characterization of the Positive Clones]." Sheng Wu Gong Cheng Xue Bao 24, no. 5 (May 2008): 733-9. [52]Tao, L. H., L. X. Yao, Z. Q. Fu, X. G. Feng, J. M. Liu, Y. J. Shi, C. X. Yuan, Y. M. Cai, and J. J. Lin. "[Cloning, Expression and Characterization of a Gene Encoding Signal Transduction Protein Wnt4 of Schistosoma Japonicum]." Sheng Wu Gong Cheng Xue Bao 23, no. 3 (May 2007): 392-7. [53]Sun, Y., R. C. Jia, J. M. Liu, C. X. Yuan, Y. J. Shi, K. Lu, Z. Q. Fu, et al. "[Construction of Phage Display Cdna Library from Adult Worms of Schistosoma Japonicum]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 25, no. 5 (Oct 2007): 406-10. [54]Wang, X. Z., Z. Q. Fu, S. P. Huang, G. Q. Zhu, Y. M. Cai, and J. J. Lin. "[Studies on Phage Displayed Mimotopes of a Protective Monoclonal Antibody (Ssj14) against Schistosoma Japonicum]." Sheng Wu Gong Cheng Xue Bao 22, no. 1 (Jan 2006): 119-24. [55]Cheng, G. F., J. J. Lin, Y. Shi, Y. X. Jin, Z. Q. Fu, Y. M. Jin, Y. C. Zhou, and Y. M. Cai. "Dose-Dependent Inhibition of Gynecophoral Canal Protein Gene Expression in Vitro in the Schistosome (Schistosoma Japonicum) by Rna Interference." Acta Biochim Biophys Sin (Shanghai) 37, no. 6 (Jun 2005): 386-90. [56]Cheng, G. F., J. J. Lin, X. G. Feng, Z. Q. Fu, Y. M. Jin, C. X. Yuan, Y. C. Zhou, and Y. M. Cai. "Proteomic Analysis of Differentially Expressed Proteins between the Male and Female Worm of Schistosoma Japonicum after Pairing." Proteomics 5, no. 2 (Feb 2005): 511-21. [57]Liu, J. M., X. Z. Cai, J. J. Lin, Z. Q. Fu, G. Z. Yang, F. H. Shi, Y. M. Cai, et al. "Gene Cloning, Expression and Vaccine Testing of Schistosoma Japonicum Sjfabp." Parasite Immunol 26, no. 8-9 (Aug-Sep 2004): 351-8. [58]Zhang, L., G. F. Cheng, Z. Q. Fu, Y. M. Jin, X. G. Feng, C. X. Yuan, Y. M. Cai, and J. J. Lin. "[Cloning, Expressing and Functional Analysis of Sjmf4, a Novel Schistosoma Japonicum Gene]." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35, no. 12 (Dec 2003): 1099-104. [59]Jin, Y. M., J. J. Lin, L. Zhang, Z. Q. Fu, X. F. Wu, Y. C. Zhou, and Y. M. Cai. "[Cloning and Expression of 21.7 Kd Protein Gene of Schistosoma Japonicum (Chinese Strain)]." Sheng Wu Gong Cheng Xue Bao 18, no. 6 (Nov 2002): 698-702. [60]Liu, J., X. Cai, J. Lin, G. Yang, X. Shen, Z. Fu, F. Shi, et al. "[Expression of Schistosoma Japonicun Fatty Acid Binding Protein Gene in Silkworm Cells and Larvae]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17, no. 4 (1999): 218-21.